Lactate‐induced metabolic remodeling and myofiber type transitions via activation of the Ca2+‐NFATC1 signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31290
Abstract: Lactate can serve as both an energy substrate and a signaling molecule, exerting diverse effects on skeletal muscle physiology. Due to the apparently positive effects, it would be interesting to consider it as a sports… read more here.
Keywords: myofiber type; physiology; metabolic remodeling; ca2 ... See more keywords
Metabolic remodeling of substrate utilization during heart failure progression
Sign Up to like & getrecommendations! Published in 2018 at "Heart Failure Reviews"
DOI: 10.1007/s10741-018-9713-0
Abstract: Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human… read more here.
Keywords: heart; metabolic remodeling; heart failure; substrate utilization ... See more keywords
Mitochondrial metabolic remodeling involved in the progression of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.484
Abstract: Pathogenesis of Alzheimer's disease (AD) affects not only central nervous system, but also peripheral glucose and lipid metabolism. We recently find the hepatic mitochondrial metabolic remodeling arises at the early stage of AD. For example,… read more here.
Keywords: metabolic remodeling; alzheimer disease; involved progression; remodeling involved ... See more keywords
Identification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2068882
Abstract: ABSTRACT Cardiac remodeling is the primary pathological feature of chronic heart failure. Prompt inhibition of remodeling in acute coronary syndrome has been a standard procedure, but the morbidity and mortality are still high. Exploring the… read more here.
Keywords: mitochondrion; ischemia; early ischemia; metabolic remodeling ... See more keywords
Metabolic Remodeling During the Early Phase of Spontaneous Seizure Emergence Highlights Hexosamine Biosynthetic Pathway Dysregulation in Temporal Lobe Epilepsy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neurochemistry"
DOI: 10.1111/jnc.70314
Abstract: Temporal lobe epilepsy (TLE) is a prevalent form of drug‐resistant epilepsy characterized by profound biochemical alterations. Emerging evidence suggests that metabolic dysregulation plays a crucial role in the development of TLE. In this study, we… read more here.
Keywords: metabolic remodeling; seizure emergence; temporal lobe; epilepsy ... See more keywords
Abstract Mo026: ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.mo026
Abstract: Background: Metabolic remodeling is a hallmark of the failing heart. Oncometabolic stress during cancer increases the activity and abundance of the ATP-dependent citrate lyase (ACL, Acly ), which promotes histone acetylation and cardiac adaptation. ACL… read more here.
Keywords: dependent citrate; citrate lyase; metabolic remodeling; heart ... See more keywords
Emodin Exerts its Therapeutic Effects Through Metabolic Remodeling in Severe Acute Pancreatitis-Related Intestinal Injury
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DOI: 10.1177/1934578x231163995
Abstract: Background Intestinal injury caused by severe acute pancreatitis (SAP) can induce peripancreatic and systemic infection, and aggravate systemic inflammation. Emodin has demonstrated efficacy in mitigating SAP-associated intestinal injury. Although metabolites in tissues cause histopathophysiological changes,… read more here.
Keywords: metabolism; severe acute; emodin; metabolic remodeling ... See more keywords
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1
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DOI: 10.1186/s12915-024-02100-y
Abstract: Age-related kidney impairment, characterized by tubular epithelial cell senescence and renal fibrosis, poses a significant global public health threat. Although N6-methyladenosine (m6A) methylation is implicated in various pathological processes, its regulatory mechanism in kidney aging… read more here.
Keywords: kidney aging; m6a; glis1; metabolic remodeling ... See more keywords
Editorial: Epithelial-Mesenchymal Transition: Yet Another Exciting Avenue in Cancer Metabolic Remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.628664
Abstract: Metastasis is a multistep process during which secondary tumors are formed in distant organs. The first step of a metastatic cascade is the epithelial-mesenchymal transition (EMT). EMT requires complex expression changes leading to the transformation… read more here.
Keywords: mesenchymal transition; emt; metabolic remodeling; epithelial mesenchymal ... See more keywords
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01255
Abstract: Background Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart. So, trimetazidine commonly… read more here.
Keywords: trimetazidine; ketone body; heart; metabolic remodeling ... See more keywords
Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.813272
Abstract: Background and Purpose: Atrial metabolic remodeling plays a critical role in the pathogenesis of atrial fibrillation (AF). Sirtuin3 (Sirt3) plays an important role in energy homeostasis. However, the effect of Sirt3 agonist Honokiol (HL) on… read more here.
Keywords: sirt3 pathway; atrial metabolic; atrial fibrillation; metabolic remodeling ... See more keywords