Metabolic remodeling of substrate utilization during heart failure progression
Sign Up to like & getrecommendations! Published in 2018 at "Heart Failure Reviews"
DOI: 10.1007/s10741-018-9713-0
Abstract: Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human… read more here.
Keywords: heart; metabolic remodeling; heart failure; substrate utilization ... See more keywords
Mitochondrial metabolic remodeling involved in the progression of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.484
Abstract: Pathogenesis of Alzheimer's disease (AD) affects not only central nervous system, but also peripheral glucose and lipid metabolism. We recently find the hepatic mitochondrial metabolic remodeling arises at the early stage of AD. For example,… read more here.
Keywords: metabolic remodeling; alzheimer disease; involved progression; remodeling involved ... See more keywords
Identification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2068882
Abstract: ABSTRACT Cardiac remodeling is the primary pathological feature of chronic heart failure. Prompt inhibition of remodeling in acute coronary syndrome has been a standard procedure, but the morbidity and mortality are still high. Exploring the… read more here.
Keywords: mitochondrion; ischemia; early ischemia; metabolic remodeling ... See more keywords
Emodin Exerts its Therapeutic Effects Through Metabolic Remodeling in Severe Acute Pancreatitis-Related Intestinal Injury
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231163995
Abstract: Background Intestinal injury caused by severe acute pancreatitis (SAP) can induce peripancreatic and systemic infection, and aggravate systemic inflammation. Emodin has demonstrated efficacy in mitigating SAP-associated intestinal injury. Although metabolites in tissues cause histopathophysiological changes,… read more here.
Keywords: metabolism; severe acute; emodin; metabolic remodeling ... See more keywords
Editorial: Epithelial-Mesenchymal Transition: Yet Another Exciting Avenue in Cancer Metabolic Remodeling
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.628664
Abstract: Metastasis is a multistep process during which secondary tumors are formed in distant organs. The first step of a metastatic cascade is the epithelial-mesenchymal transition (EMT). EMT requires complex expression changes leading to the transformation… read more here.
Keywords: mesenchymal transition; emt; metabolic remodeling; epithelial mesenchymal ... See more keywords
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01255
Abstract: Background Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart. So, trimetazidine commonly… read more here.
Keywords: trimetazidine; ketone body; heart; metabolic remodeling ... See more keywords
Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.813272
Abstract: Background and Purpose: Atrial metabolic remodeling plays a critical role in the pathogenesis of atrial fibrillation (AF). Sirtuin3 (Sirt3) plays an important role in energy homeostasis. However, the effect of Sirt3 agonist Honokiol (HL) on… read more here.
Keywords: sirt3 pathway; atrial metabolic; atrial fibrillation; metabolic remodeling ... See more keywords
New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.831829
Abstract: Cardiac function highly relies on sufficient energy supply. Perturbations in myocardial energy metabolism play a causative role in cardiac pathogenesis. Accumulating evidence has suggested that modifications of cardiac metabolism are also an essential part of… read more here.
Keywords: energy substrate; energy; physiological adaption; metabolic remodeling ... See more keywords
Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Antioxidants"
DOI: 10.3390/antiox8110505
Abstract: Peroxiredoxin 6 (Prdx6) is the only member of 1-Cys subfamily of peroxiredoxins in human cells. It is the only Prdx acting on phospholipid hydroperoxides possessing two additional sites with phospholipase A2 (PLA2) and lysophosphatidylcholine-acyl transferase… read more here.
Keywords: cycle arrest; metabolic remodeling; cell cycle; cycle ... See more keywords
Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11080517
Abstract: Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific… read more here.
Keywords: skeletal muscle; metabolic remodeling; muscle; muscle atrophy ... See more keywords
Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020814
Abstract: When the expression of NOS2 in M1-polarized macrophages is induced, huge amounts of nitric oxide (•NO) are produced from arginine and molecular oxygen as the substrates. While anti-microbial action is the primary function of M1… read more here.
Keywords: oxide protecting; radical species; nitric oxide; polarized macrophages ... See more keywords