Metabolic reprogramming heterogeneity in chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13568
Abstract: Fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of chronic kidney disease (CKD). Myofibroblasts, which are the cells responsible for ECM production, are activated by cross-talk with injured proximal tubule and… read more here.
Keywords: metabolic reprogramming; reprogramming heterogeneity; chronic kidney; kidney disease ... See more keywords
Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic‐co‐glycolic acid), and Silica Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201601240
Abstract: &NA; Monitoring macrophage metabolism in response to nanoparticle exposure provides new insights into biological outcomes, such as inflammation or toxicity, and supports the design of tailored nanomedicines. This paper describes the metabolic signature of macrophages… read more here.
Keywords: poly lactic; metabolic reprogramming; reprogramming macrophages; silk poly ... See more keywords
A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104134
Abstract: Abstract Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor immunosurveillance and improve leukemia targeting‐therapy… read more here.
Keywords: immunosurveillance; cell; leukemia; metabolic reprogramming ... See more keywords
Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204808
Abstract: Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives immunosuppression and promotes tumor progression. Material‐engineered strategies for intratumoral lactate modulations demonstrate their promise for tumor immunotherapy. However, understanding of the inherent interconnections of material‐enabled… read more here.
Keywords: lactate depletion; intratumoral lactate; lactate; metabolic reprogramming ... See more keywords
Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12285
Abstract: Dear Editor, Immune-directed therapeutic approaches have changed the paradigm of cancer treatment. The tumor-immune microenvironment [1] is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen, nutrient deficiency, acidity, and interactions betweenmultiple… read more here.
Keywords: intercellular communications; metabolic reprogramming; differences metabolic; gastric cancer ... See more keywords
Identification of a metabolic reprogramming‐related signature associated with prognosis and immune microenvironment of head and neck squamous cell carcinoma by in silico analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4670
Abstract: Metabolic reprogramming is one of the essential features of tumorigenesis. Herein, this study aimed to develop a novel metabolism‐related gene signature for head and neck squamous cell carcinoma (HNSCC) patients. read more here.
Keywords: cell carcinoma; head neck; signature; squamous cell ... See more keywords
The role of metabolic reprogramming in γ‐herpesvirus‐associated oncogenesis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30795
Abstract: The γ‐herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ‐herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have… read more here.
Keywords: metabolic reprogramming; herpesvirus associated; reprogramming herpesvirus; role metabolic ... See more keywords
The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34040
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with… read more here.
Keywords: hepatocellular carcinoma; hcc; noncoding rnas; metabolic reprogramming ... See more keywords
The mitochondrial metabolic reprogramming agent trimetazidine as an ‘exercise mimetic’ in cachectic C26‐bearing mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12226
Abstract: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function.… read more here.
Keywords: metabolic reprogramming; muscle; trimetazidine; reprogramming agent ... See more keywords
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23531
Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest human malignancies characterized by late‐stage diagnosis, drug resistance, and poor prognosis. Pyruvate dehydrogenase kinase 1 (PDK1) plays an important role in regulating the metabolic reprogramming… read more here.
Keywords: cell; pdk1; progression; squamous cell ... See more keywords
Metabolic Reprogramming and Signaling to Chromatin Modifications in Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-34025-4_12
Abstract: Cellular proliferation relies on a high energetic status, replenished through nutrient intake, that leads to the production of biosynthetic material. A communication between the energetic levels and the control of gene expression is essential to… read more here.
Keywords: metabolic reprogramming; metabolic pathways; signaling chromatin; reprogramming signaling ... See more keywords