CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.11.008
Abstract: SUMMARY Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of resistance to HER2 inhibition, metabolic… read more here.
Keywords: cancer; metabolic rewiring; resistance her2; breast cancer ... See more keywords
Deciphering metabolic rewiring in breast cancer subtypes
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2017.07.004
Abstract: &NA; Metabolic reprogramming, an emerging hallmark of cancer, is observed in breast cancer. Breast cancer cells rewire their cellular metabolism to meet the demands of survival, proliferation, and invasion. However, breast cancer is a heterogeneous… read more here.
Keywords: metabolic rewiring; rewiring breast; deciphering metabolic; breast cancer ... See more keywords
UVB Drives Metabolic Rewiring and Epigenetic Reprograming and Protection by Sulforaphane in Human Skin Keratinocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00432
Abstract: Sulforaphane (SFN) is a potent anticancer agent which could protect the skin from ultraviolet (UV) radiation-induced insults. Currently, the metabolic rewiring and epigenetic reprograming induced by UVB and the role of SFN in UVB-mediated skin… read more here.
Keywords: uvb drives; sfn; epigenetic reprograming; metabolic rewiring ... See more keywords
Global Metabolic Rewiring of Yeast Enables Overproduction of Sesquiterpene (+)-Valencene.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01394
Abstract: (+)-Valencene is a bioactive sesquiterpene that can be used for flavoring and fragrances, and microbial production provides an alternative sustainable access. However, the complexity of cellular metabolism makes it challenging for its high-level production. Here,… read more here.
Keywords: yeast enables; global metabolic; rewiring yeast; metabolic rewiring ... See more keywords
Metabolic rewiring and redox alterations in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0661-9
Abstract: Malignant pleural mesothelioma (MPM) is a rare malignancy of mesothelial cells with increasing incidence, and in many cases, dismal prognosis due to its aggressiveness and lack of effective therapies. Environmental and occupational exposure to asbestos… read more here.
Keywords: metabolic rewiring; mpm; alterations malignant; pleural mesothelioma ... See more keywords
Obesity Promotes Metabolic Rewiring That Starves Cytotoxic T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-183
Abstract: In mice, obesity remodeled TME metabolism, reducing infiltration by CD8+ T cells and antitumor immunity. read more here.
Keywords: metabolic rewiring; rewiring starves; starves cytotoxic; promotes metabolic ... See more keywords
Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.930250
Abstract: Melanoma is a complex and aggressive cancer type that contains different cell subpopulations displaying distinct phenotypes within the same tumor. Metabolic reprogramming, a hallmark of cell transformation, is essential for melanoma cells to adopt different… read more here.
Keywords: cell; melanoma; phenotype switching; rewiring phenotype ... See more keywords
Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.901951
Abstract: Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans’ foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations of genetic alterations (GA) in GBM induce a diversity of metabolic… read more here.
Keywords: glioblastoma cancer; metabolic rewiring; rewiring glioblastoma; gbm ... See more keywords
Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers10120499
Abstract: Oncogenic properties, along with the metabolic reprogramming necessary for tumour growth and motility, are acquired by cancer cells. Thus, tumour metabolism is becoming a target for cancer therapy. Here, cancer cell metabolism was tackled by… read more here.
Keywords: metabolic rewiring; growth; vdac1; expression ... See more keywords
Metabolic Rewiring and the Characterization of Oncometabolites
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13122900
Abstract: Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor tissue or due to hypoxia. These processes result… read more here.
Keywords: metabolic rewiring; oncometabolites fumarate; hydroxyglutarate; fumarate succinate ... See more keywords
Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205058
Abstract: Simple Summary Metabolic rewiring fuels cancer proliferation by enhanced glycolysis and the increased NADH/NAD+ ratio. In this study, we highlight the critical role of NADH in the epigenetic landscape mediated by CtBP2 (C-terminal binding protein… read more here.
Keywords: metabolic rewiring; integration; metabolism; breast cancer ... See more keywords