Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2018.03.001
Abstract: Diphosphoinositol pentakisphosphate (IP7) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high Km for ATP of the IP7-generating enzymes,… read more here.
Keywords: insulin; inositol hexakisphosphate; sensor pancreatic; hexakisphosphate kinase ... See more keywords
The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz786
Abstract: Abstract The metabolic sensor Per-Arnt-Sim (Pas) domain-containing serine/threonine kinase (PASK) is expressed predominantly in the cytoplasm of different cell types, although a small percentage is also expressed in the nucleus. Herein, we show that the… read more here.
Keywords: methylation; kinase; h3k4 mll2; pask ... See more keywords