Metabolic side effects induced by olanzapine treatment are neutralized by CB1 receptor antagonist compounds co-administration in female rats
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.03.010
Abstract: Weight gain is an important side effect of most atypical antipsychotic drugs such as olanzapine. Moreover, although many animal models with metabolic side effects have been well defined, the interaction with other pathways has to… read more here.
Keywords: metabolic side; treatment; weight gain; cb1 receptor ... See more keywords
Neuropsychiatric disorders: Side effects of olanzapine worsened by metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.183
Abstract: generation antipsychotic drug, can cause metabolic side effects, including hyperphagia, weight gain and acute hyperglycaemia. Previously, researchers used lean, healthy rodents to investigate the mechanisms behind olanzapine-associated acute hyperglycaemia; however, individuals with schizophrenia are often… read more here.
Keywords: insulin; metabolic side; hyperglycaemia; mice ... See more keywords
DNA methylation may partly explain psychotropic drug-induced metabolic side effects: results from a prospective 1-month observational study
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Epigenetics"
DOI: 10.1186/s13148-024-01648-4
Abstract: Metabolic side effects of psychotropic medications are a major drawback to patients’ successful treatment. Using an epigenome-wide approach, we aimed to investigate DNA methylation changes occurring secondary to psychotropic treatment and evaluate associations between 1-month… read more here.
Keywords: month; treatment; methylation; dna methylation ... See more keywords
Metabolic Side Effects from Antipsychotic Treatment with Clozapine Linked to Aryl Hydrocarbon Receptor (AhR) Activation
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12102294
Abstract: Metabolic syndrome (MetS) is the most common adverse drug reaction from psychiatric pharmacotherapy. Neuroreceptor blockade by the antipsychotic drug clozapine induces MetS in about 30% of patients. Similar to insulin resistance, clozapine impedes Akt kinase… read more here.
Keywords: treatment; iron; clozapine; activation ... See more keywords