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   Articles with "metabolic signatures" as a keyword



Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

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recommendations! Published in 2025 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.28982

Abstract: Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular… read more here.

Keywords: flux sampling; sampling suggests; cho cells; culture ... See more keywords

Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI

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recommendations! Published in 2024 at "Obesity"

DOI: 10.1002/oby.24070

Abstract: Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist‐hip ratio. This study aimed to determine… read more here.

Keywords: hip ratio; obesity; waist hip; circumference waist ... See more keywords

Development of metabolic signatures of plant-rich dietary patterns using plant-derived metabolites

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recommendations! Published in 2024 at "European Journal of Nutrition"

DOI: 10.1007/s00394-024-03511-x

Abstract: Diet is an important modifiable lifestyle factor for human health, and plant-rich dietary patterns are associated with lower risk of non-communicable diseases in numerous studies. However, objective assessment of plant-rich dietary exposure in nutritional epidemiology… read more here.

Keywords: plant rich; plant; rich dietary; dietary patterns ... See more keywords

Metabolic signatures of regulation by phosphorylation and acetylation

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recommendations! Published in 2022 at "iScience"

DOI: 10.1016/j.isci.2021.103730

Abstract: Summary Acetylation and phosphorylation are highly conserved posttranslational modifications (PTMs) that regulate cellular metabolism, yet how metabolic control is shared between these PTMs is unknown. Here we analyze transcriptome, proteome, acetylome, and phosphoproteome datasets in… read more here.

Keywords: phosphorylation acetylation; metabolic signatures; machine learning; acetylation ... See more keywords

Identifying Metabolic Signatures of Bisphenol Analog Exposure: Implication for Rapid Toxicity Screening of New Alternatives

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recommendations! Published in 2025 at "Environmental Science & Technology"

DOI: 10.1021/acs.est.5c08697

Abstract: The lack of toxicity assessments for bisphenol A substitutes (BPs) has resulted in a vicious circle of pollution, replacement, and repollution. Herein, we aimed to develop specific biomarkers for rapid toxic screening and evaluation. We… read more here.

Keywords: identifying metabolic; toxicity; signatures bisphenol; exposure ... See more keywords
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Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

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recommendations! Published in 2018 at "Environmental science & technology"

DOI: 10.1021/acs.est.8b02215

Abstract: Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. We aimed to identify urinary… read more here.

Keywords: environmental pollutants; multiple environmental; pregnant women; exposure ... See more keywords

Multiomics and Machine Learning Reveal Distinct Immune-Metabolic Signatures and Diagnostic Biomarkers for Asthma Inflammatory Endotypes

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c07657

Abstract: Background: bronchial asthma is a highly heterogeneous chronic inflammatory disease, with eosinophilic (EA) and neutrophilic (NEA) asthma subtypes exhibiting distinct pathological mechanisms and treatment responses. However, the protein-metabolite interactions underlying the pathogenesis of asthma remain… read more here.

Keywords: immune metabolic; distinct immune; machine learning; healthy controls ... See more keywords

Uncovering metabolic signatures in cancer-derived exosomes: LC-MS/MS and NMR profiling.

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recommendations! Published in 2024 at "Nanoscale"

DOI: 10.1039/d4nr03454f

Abstract: Understanding the intricate interplay between cancer metabolism and intercellular communication within the tumour microenvironment (TME) is crucial for advancing cancer diagnostics and therapeutics. In this study, we investigate the metabolites present in exosomes derived from… read more here.

Keywords: uncovering metabolic; cancer; signatures cancer; derived exosomes ... See more keywords

Dietary metabolic signatures and cardiometabolic risk.

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recommendations! Published in 2022 at "European heart journal"

DOI: 10.1093/eurheartj/ehac446

Abstract: AIMS Observational studies of diet in cardiometabolic-cardiovascular disease (CM-CVD) focus on self-reported consumption of food or dietary pattern, with limited information on individual metabolic responses to dietary intake linked to CM-CVD. Here, machine learning approaches… read more here.

Keywords: long term; food; risk; cvd ... See more keywords

Transcriptomic and metabolic signatures of diatom plasticity to light fluctuations.

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recommendations! Published in 2022 at "Plant physiology"

DOI: 10.1093/plphys/kiac455

Abstract: Unlike in terrestrial and freshwater ecosystems, light fields in oceans fluctuate due to both horizontal current and vertical mixing. Diatoms thrive and dominate the phytoplankton community in these fluctuating light fields. However, the molecular mechanisms… read more here.

Keywords: light fluctuations; light fluctuation; transcriptomic metabolic; light ... See more keywords

Aberrant Lipid Metabolic Signatures in Acute Myeloid Leukemia.

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recommendations! Published in 2024 at "Stem cells"

DOI: 10.1093/stmcls/sxad095

Abstract: Leukemogenesis is a complex process that involves multiple stages of mutation in either hematopoietic stem or progenitor cells, leading to cancer development over time. Acute myeloid leukemia (AML) is an aggressive malignancy that affects myeloid… read more here.

Keywords: lipid metabolic; lipid metabolism; acute myeloid; leukemia ... See more keywords