Cerebral oxygen metabolic stress is increased in children with sickle cell anemia compared to anemic controls
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26485
Abstract: Patients with sickle cell anemia (SCA) experience cerebral metabolic stress with an increase in oxygen extraction fraction (OEF) to compensate for reduced oxygen carrying capacity due to anemia. It remains unclear if anemia alone drives… read more here.
Keywords: sca; metabolic stress; oef; oxygen ... See more keywords
Breviscapine Alleviates Nonalcoholic Steatohepatitis by Inhibiting TGF-β-activated Kinase 1-dependent Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32221
Abstract: BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is a key component of metabolic syndrome ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and is now becoming the leading cause of cirrhosis and… read more here.
Keywords: metabolic stress; breviscapine; signaling breviscapine; nonalcoholic steatohepatitis ... See more keywords
Acetyl‐CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30355
Abstract: ACSS1/2 converts acetate into acetyl‐coenzyme A, which contributes to histone acetylation in the mitochondria and cytoplasm. Zygotic genome activation (ZGA) is critical for embryo development involving drastic histone modification. An efficient crRNAs‐Cas13a targeting strategy was… read more here.
Keywords: acss1; histone acetylation; acetylation; metabolic stress ... See more keywords
Effect of Metabolic Stress on Lysosomal Proteolysis in the Liver and Brain of Rats Receiving Q10-Enriched Ration
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4156-0
Abstract: Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues… read more here.
Keywords: lysosomal proteolysis; metabolic stress; liver brain; brain rats ... See more keywords
11β-HSD1 Inhibition Rescues SAMP8 Cognitive Impairment Induced by Metabolic Stress
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01708-4
Abstract: Ageing and obesity have been shown to increase the risk of cognitive decline and Alzheimer’s disease (AD). Besides, elevated glucocorticoid (GCs) levels cause metabolic stress and have been associated with the neurodegenerative process. Direct pieces… read more here.
Keywords: hsd1; metabolic stress; treatment; inhibition ... See more keywords
PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.199
Abstract: Mitochondria play an important role in cellular metabolism and are closely related with metabolic stress. Recently, several studies have shown that mitophagy mediated by PTEN-induced putative kinase 1 (PINK1) and Parkin may play a critical… read more here.
Keywords: pink1 parkin; 3t3 preadipocytes; adipose tissue; metabolic stress ... See more keywords
Regulating the Warburg effect on metabolic stress and myocardial fibrosis remodeling and atrial intracardiac waveform activity induced by atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.055
Abstract: Atrial fibrillation (AF) is associated with metabolic stress and induces myocardial fibrosis reconstruction by increasing glycolysis. One goal in the treatment of paroxysmal AF (p-AF) is to improve myocardial fibrosis reconstruction and myocardial metabolic stress… read more here.
Keywords: fibrosis; metabolic stress; myocardial fibrosis; warburg effect ... See more keywords
Metabolic stress leads to divergent changes in the ghrelinergic system in goldfish (Carassius auratus) gonads.
Sign Up to like & getrecommendations! Published in 2019 at "Comparative biochemistry and physiology. Part A, Molecular & integrative physiology"
DOI: 10.1016/j.cbpa.2019.05.027
Abstract: Various endocrine factors that regulate energy homeostasis are also implicated in the reproductive physiology of mammals. However, the hormonal link between metabolism and reproduction in fish is poorly understood. Ghrelin is a multifunctional hormone with… read more here.
Keywords: system; metabolic stress; ghrelinergic system; physiology ... See more keywords
Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.08.009
Abstract: FGF21 is a multifunctional metabolic and stress hormone which is normally expressed in liver but cellular stress, e.g. mitochondrial or endoplasmic reticulum (ER) stress, can induce its expression and subsequent secretion from several mammalian tissues.… read more here.
Keywords: longevity; metabolic stress; integrated stress; stress ... See more keywords
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.008
Abstract: Cellular homeostasis is coordinated through communication between mitochondria and the nucleus, organelles that each possess their own genomes. Whereas the mitochondrial genome is regulated by factors encoded in the nucleus, the nuclear genome is currently… read more here.
Keywords: response; metabolic stress; gene expression; translocates nucleus ... See more keywords
Metabolic stress promotes sustained activation of protein phosphatase 2A (PP2A) in the islet beta-cell: novel regulation by alpha4, a non-canonical subunit of PP2A
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.201
Abstract: Purpose Despite emerging evidence suggesting requisite roles for protein kinases in islet beta-cell function, protein phosphatases remain an under studied area in islet biology. The PP2A, which accounts for 80% of total serine/threonine phosphatases, has… read more here.
Keywords: islet; metabolic stress; pp2a; beta ... See more keywords