Neurotoxicity of ischemic astrocytes involves STAT3‐mediated metabolic switching and depends on glycogen usage
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24357
Abstract: Astrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of astrocyte‐mediated neurotoxicity remain elusive. Here,… read more here.
Keywords: ischemic astrocytes; stat3; metabolic switching; glycogen usage ... See more keywords
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00537-z
Abstract: Intermittent fasting (IF) remains the most effective intervention to achieve robust anti-aging effects and attenuation of age-related diseases in various species. Epigenetic modifications mediate the biological effects of several environmental factors on gene expression; however,… read more here.
Keywords: intermittent fasting; epigenomic transcriptomic; transcriptomic analyses; integrative epigenomic ... See more keywords
Identification of D-Limonene Metabolites by LC-HRMS: An Exploratory Metabolic Switching Approach in a Mouse Model of Diet-Induced Obesity
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DOI: 10.3390/metabo12121246
Abstract: Metabolic switching has been raised as an important phenomenon to be studied in relation to xenobiotic metabolites, since the dose of the exposure determines the formation of metabolites and their bioactivity. Limonene is a monoterpene… read more here.
Keywords: phase metabolites; limonene; diet induced; metabolic switching ... See more keywords
Platform for "Chemical Metabolic Switching" to Increase Sesquiterpene Content in Plants.
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DOI: 10.5511/plantbiotechnology.17.0114a
Abstract: The biosynthetic pathway of cytosolic isoprenoids bifurcates after farnesyl diphosphate into sesquiterpene and triterpene pathways. "Metabolic switching" has been used to increase sesquiterpene content in plants by suppressing the competitive triterpene pathway using transgenic technology.… read more here.
Keywords: metabolic switching; sesquiterpene; chemical metabolic; amorpha diene ... See more keywords