Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.018
Abstract: Tumors, including melanomas, frequently show an accelerated glucose metabolism. Mutations in the v-Raf murine sarcoma viral oncogene homolog B (BRAF), detected in about 50% of all melanomas, result in further enhancement of glycolysis. Therefore anti-metabolic… read more here.
Keywords: melanoma; targeting synergizes; metabolic targeting; resistance ... See more keywords
Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16767
Abstract: Glioblastomas are characterized by amplification of EGFR. Approximately half of tumors with EGFR over-expression also express a constitutively active ligand independent EGFR variant III (EGFRvIII). While current treatments emphasize surgery followed by radiation and chemotherapy… read more here.
Keywords: targeting egfrviii; pdk1 axis; egfrviii pdk1; metabolic targeting ... See more keywords