The architecture and metabolic traits of monospecific photosynthetic biofilms studied in a custom flow‐through system
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28147
Abstract: Microalgae biofilms have great ecological importance and high biotechnological potential. Nevertheless, an in‐depth and combined structural (i.e., the architecture of the biofilm) and physiological characterization of microalgae biofilms is still missing. An approach able to… read more here.
Keywords: photosynthetic biofilms; custom flow; architecture metabolic; traits monospecific ... See more keywords
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4947-5
Abstract: Aims/hypothesisCirculating succinate and 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) were recently shown to promote brown adipocyte thermogenesis and protect against metabolic disorders in rodents. This study aimed to evaluate the associations between plasma levels of these metabolites and… read more here.
Keywords: plasma; succinate dihome; plasma succinate; adiposity ... See more keywords
Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population
Sign Up to like & getrecommendations! Published in 2020 at "Human Genetics"
DOI: 10.1007/s00439-020-02222-7
Abstract: While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for metabolic traits. Determining the transferability of such largely Euro-centric established… read more here.
Keywords: association signals; genome wide; risk; metabolic traits ... See more keywords
Unique metabolic traits identify CCPAP
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-019-0151-6
Abstract: Renal cell carcinoma (RCC) is often caused by genetic mutations that disrupt cellular metabolism. In clear cell papillary RCC (CCPAP), driver mutations are absent but mitochondrial changes still result in a unique metabolic profile, according… read more here.
Keywords: traits identify; unique metabolic; rcc; ccpap ... See more keywords
Genetic architecture and regulatory impact on hepatic microRNA expression linked to immune and metabolic traits
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170101
Abstract: Regulation of microRNA (miRNA) expression contributes to a wide range of target gene expression and phenotypes. The miRNA expression in the liver, the central metabolic organ, was examined in 209 pigs, and integrated with haematological… read more here.
Keywords: immune metabolic; mirna; mir; expression levels ... See more keywords
Can metabolic traits explain animal community assembly and functioning?
Sign Up to like & getrecommendations! Published in 2022 at "Biological Reviews"
DOI: 10.1111/brv.12892
Abstract: All animals on Earth compete for free energy, which is acquired, assimilated, and ultimately allocated to growth and reproduction. Competition is strongest within communities of sympatric, ecologically similar animals of roughly equal size (i.e. horizontal… read more here.
Keywords: animal communities; ecology; assembly functioning; animal community ... See more keywords
Genetics of metabolic traits in Greenlanders: lessons from an isolated population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12814
Abstract: In this review, we describe the extraordinary population of Greenland, which differs from large outbred populations of Europe and Asia, both in terms of population history and living conditions. Many years in isolation, small population… read more here.
Keywords: greenlanders lessons; genetics; genetics metabolic; metabolic traits ... See more keywords
Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00140.2020
Abstract: Mice have provided critical mechanistic understandings of clinical traits underlying Metabolic Syndrome (MetSyn) and susceptibility to MetSyn in mice is known to vary among inbred strains. We investigated the diet- and strain-dependent effects on metabolic… read more here.
Keywords: strain; liver triglyceride; collaborative cross; metabolic traits ... See more keywords
Abstract MP74: The Effect Of BMI On Metabolic Traits Is Mediated By A Novel Diabetes Marker
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circ.145.suppl_1.mp74
Abstract: Introduction: 2-aminoadipic acid (2-AAA) secreted during adipogenesis is a novel marker for diabetes. Hypothesis: 2-AAA mediates the associations between body mass index (BMI) and metabolic measures, and the effect of 2-AAA can be modified by… read more here.
Keywords: effect; beta; bmi metabolic; metabolic traits ... See more keywords
Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population
Sign Up to like & getrecommendations! Published in 2017 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-017-0644-x
Abstract: BackgroundLeptin acts as a mediator of inflammation and energy homeostasis by activating leptin receptor (LEPR). We conducted this study to explore the association of polymorphisms in LEPR with type 2 diabetes mellitus (T2DM) and its… read more here.
Keywords: related metabolic; lepr type; polymorphisms lepr; association polymorphisms ... See more keywords
MON-186 An Evaluation of the Ability of Current Exome Sequence Datasets to Retrospectively Validate Drugs for T2D or Related Metabolic Traits
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-186
Abstract: Abstract Human genetics offers the potential to inform on the viability of therapeutic targets through the identification of associations between naturally occurring genetic variants and clinical outcomes. Whole Exome Sequencing (WES) enables comprehensive analysis of… read more here.
Keywords: related metabolic; drug; level; gene ... See more keywords