Abstract 5849: Association between annexin-A6 expression and metabolic vulnerabilities of TNBC cells and their response to EGFR-tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5849
Abstract: PURPOSE: Triple-negative breast cancer (TNBC), and the basal-like TNBC subtype, accounts for ~20% of all breast cancer (BC) cases, and is particularly prevalent in younger patients of African-American and Hispanic descent. The importance of annexin… read more here.
Keywords: kinase inhibitors; anxa6; metabolic vulnerabilities; tnbc cells ... See more keywords
Abstract 6718: Exploiting metabolic vulnerabilities of pediatric rhabdomyosarcoma with novelnicotinamide phosphoribosyltransferase (NAMPT) inhibitor OT-82
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DOI: 10.1158/1538-7445.am2023-6718
Abstract: Purpose: A hallmark of cancer cells is altered metabolism. Therapeutically, these alterations may be exploited by targeting metabolic vulnerabilities specific to cancer cells. Efficient production of NAD through the NAD salvage pathway is one such… read more here.
Keywords: cell lines; cancer; nampt inhibitor; metabolic vulnerabilities ... See more keywords
Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
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DOI: 10.3390/ijms23073745
Abstract: Melanoma is characterized by high glucose uptake, partially mediated through elevated pyruvate dehydrogenase kinase (PDK), making PDK a potential treatment target in melanoma. We aimed to reduce glucose uptake in melanoma cell lines through PDK… read more here.
Keywords: inhibition; melanoma; metabolic vulnerabilities; dehydrogenase kinase ... See more keywords