1898-P: The Role of the Diabetes Gene and Wnt Pathway Effector TCF7L2 in Hepatic Metabolic Zonation
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1898-p
Abstract: The Transcription Factor 7-like 2 (TCF7L2) gene is associated with type 2 diabetes (T2D), but the function of the protein in metabolic tissues is controversial. The liver regulates whole body lipid and carbohydrate metabolism, and… read more here.
Keywords: metabolic zonation; hep e11; hepatic metabolic; tcf7l2 ... See more keywords
Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00524
Abstract: Pre-clinical drug screening is an important step in assessing the metabolic effects and hepatic toxicity of new pharmaceutical compounds. However, due to the complexity of the liver microarchitecture, simplified in vitro models do not adequately… read more here.
Keywords: oxygen; drug; oxygen concentration; zonation ... See more keywords