Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.
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DOI: 10.1021/acs.biochem.7b00595
Abstract: Recent proteomic studies discovered histone lysines are modified by acylations beyond acetylation. These acylations derive from acyl-CoA metabolites, potentially linking metabolism to transcription. Bromodomains bind lysine acylation on histones and other nuclear proteins to influence… read more here.
Keywords: binding bet; bet bromodomains; bet; metabolically derived ... See more keywords