Integrated proteomics identifies troponin I isoform switch as a regulator of a sarcomere-metabolism axis during cardiac regeneration.
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DOI: 10.1093/cvr/cvaf069
Abstract: AIMS Adult mammalian cardiomyocytes have limited regenerative potential, and after myocardial infarction (MI), injured cardiac tissue is replaced with fibrotic scar. In contrast, the neonatal mouse heart possesses a regenerative capacity governed by cardiomyocyte proliferation;… read more here.
Keywords: sarcomere metabolism; isoform switch; metabolism axis; metabolism ... See more keywords