Lipid Metabolism in Cancer Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6785-2_4
Abstract: Metabolic reprogramming is one of the most critical hallmarks in cancer cells. In the past decades, mounting evidence has demonstrated that, besides the Warburg Effect, lipid metabolism dysregulation is also one of the essential characteristics… read more here.
Keywords: metabolism cancer; biology; cancer cells; cancer ... See more keywords
Role of 27-hydroxycholesterol and its metabolism in cancer progression: human studies.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114618
Abstract: Direct translation of findings achieved in experimental cell or animal models to humans is quite a difficult task. We focused here only on the epidemiological and ex vivo human studies so far available about the… read more here.
Keywords: role hydroxycholesterol; metabolism cancer; human studies; role ... See more keywords
Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.05.002
Abstract: One of the most important metabolic hallmarks of cancer cells is deregulation of lipid metabolism. In addition, enhancing de novo fatty acid (FA) synthesis, increasing lipid uptake and lipolysis have also been considered as means… read more here.
Keywords: therapeutic strategy; metabolism cancer; cancer cells; cancer ... See more keywords
Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103366
Abstract: Summary Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the systematic collection of metabolic… read more here.
Keywords: mitochondrial shutdown; metabolism cancer; cancer cells; cancer ... See more keywords
Metabolism and cancer: the future is now
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DOI: 10.1038/s41416-019-0667-3
Abstract: In the last decade, the field of cancer metabolism transformed itself from being a description of the metabolic features of cancer cells to become a key component of cellular transformation. Now, the potential role of… read more here.
Keywords: metabolism; metabolism cancer; biology; cancer ... See more keywords
The Janus-like role of proline metabolism in cancer
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DOI: 10.1038/s41420-020-00341-8
Abstract: The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread. Pyrroline-5-carboxylate reductase (PYCR) and proline dehydrogenase (PRODH) enzymes,… read more here.
Keywords: role proline; metabolism; metabolism cancer; proline metabolism ... See more keywords
Insulin and cancer: a tangled web
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210134
Abstract: For a century, since the pioneering work of Otto Warburg, the interwoven relationship between metabolism and cancer has been appreciated. More recently, with obesity rates rising in the U.S. and worldwide, epidemiologic evidence has supported… read more here.
Keywords: metabolism cancer; cancer tangled; insulin cancer; cancer ... See more keywords
TRAP1 suppresses oral squamous cell carcinoma progression by reducing oxidative phosphorylation metabolism of Cancer-associated fibroblasts
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DOI: 10.1186/s12885-021-09049-z
Abstract: Background Glucose metabolism in cancer associated fibroblasts (CAFs) within the tumor microenvironment is a material and energy source for tumorigenesis and tumor development. However, the characteristics and important regulatory mechanisms of glucose metabolism in fibroblasts… read more here.
Keywords: cafs; cancer associated; associated fibroblasts; metabolism ... See more keywords
The Tangled Mitochondrial Metabolism In Cancer: An Innovative Pharmacological Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190823163009
Abstract: BACKGROUND Mitochondria remarkably gaining significant and different pathogenic roles in cancer (i.e., to sustain specific metabolism, to activate signaling pathways, to promote apoptosis resistance, to favor cancer cell dissemination, and finally to facilitate genome instability).… read more here.
Keywords: metabolism; metabolism cancer; mitochondrial metabolism; cancer cells ... See more keywords
Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230522103321
Abstract: It is now an undisputed fact that cancer cells undergo metabolic reprogramming to support their malignant phenotype, and it is one of the crucial hallmarks which enables cancer cells to facilitate their survival under variable… read more here.
Keywords: metabolism cancer; cancer; lipid metabolism; aberrant lipid ... See more keywords
Interplay Between m6A RNA Methylation and Regulation of Metabolism in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.813581
Abstract: Methylation of adenosine in RNA to N6-methyladenosine (m6A) is widespread in eukaryotic cells with his integral RNA regulation. This dynamic process is regulated by methylases (editors/writers), demethylases (remover/erasers), and proteins that recognize methylation (effectors/readers). It… read more here.
Keywords: metabolism cancer; metabolism; methylation; m6a modification ... See more keywords