Intestinal metabolism of diclofenac by polymorphic UGT2B17 correlates with its highly variable pharmacokinetics and safety across populations.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2907
Abstract: Although the United States and Europe have shifted to the prescription use of diclofenac due to several serious incidences of cardiotoxicity, it is one of the most commonly used over-the-counter (OTC) medicine in major parts… read more here.
Keywords: metabolism; intestinal metabolism; metabolism diclofenac; diclofenac polymorphic ... See more keywords
Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study.
Sign Up to like & getrecommendations! Published in 2019 at "Marine pollution bulletin"
DOI: 10.1016/j.marpolbul.2019.02.050
Abstract: Interest in the presence of pharmaceutically active compounds in the aquatic environment has been growing for over 20 years, yet very few studies deal with the metabolism of pharmaceuticals in marine organisms. In this study, the… read more here.
Keywords: study; mytilus trossulus; metabolism diclofenac; concentration ... See more keywords