Reproducibility of Adipogenic Responses to Metabolism Disrupting Chemicals in the 3T3-L1 Pre-adipocyte Model System: An Interlaboratory Study.
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DOI: 10.1016/j.tox.2021.152900
Abstract: The 3T3-L1 murine pre-adipocyte line is an established cell culture model for screening Metabolism Disrupting Chemicals (MDCs). Despite a need to accurately identify MDCs for further evaluation, relatively little research has been performed to comprehensively… read more here.
Keywords: metabolism disrupting; pre; model; disrupting chemicals ... See more keywords
Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models
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DOI: 10.3390/ijms23084182
Abstract: Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials,… read more here.
Keywords: vitro; disrupting chemicals; pancreatic cell; metabolism disrupting ... See more keywords
In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model
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DOI: 10.3390/ijms23095040
Abstract: There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and dispersed mouse islet cells to… read more here.
Keywords: cell; cell model; metabolism disrupting; diabetogenic activity ... See more keywords
Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
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DOI: 10.3390/ijms24032686
Abstract: The liver is the central metabolic organ of the body. The plethora of anabolic and catabolic pathways in the liver is tightly regulated by physiological signaling but may become imbalanced as a consequence of malnutrition… read more here.
Keywords: metabolism; affecting liver; identification; metabolism disrupting ... See more keywords