Metabolism and excretion of the benzodiazepine analog etizolam in the horse.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2967
Abstract: Etizolam is a benzodiazepine analog that is approved for use in Japan, Italy, and India, but has recently appeared as a non-approved product on the illicit drug market in Europe and North America. Etizolam was… read more here.
Keywords: metabolism; benzodiazepine analog; drug; metabolism excretion ... See more keywords
Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00160
Abstract: Absorption, distribution, metabolism, and excretion (ADME), which collectively define the concentration profile of a drug at the site of action, are of critical importance to the success of a drug candidate. Recent advances in machine… read more here.
Keywords: metabolism excretion; learning algorithms; distribution metabolism; machine learning ... See more keywords
Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2019.1581960
Abstract: Abstract 1. The absorption, metabolism, and excretion of a single oral 450-mg dose of [14C]-(S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, was investigated in humans. Mass balance was achieved with ∼94.6% of the administered dose… read more here.
Keywords: trifluoromethyl imidazol; imidazol propanamido; cyclopentyl; metabolism ... See more keywords
The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.2002973
Abstract: Abstract The metabolism and excretion of cetagliptin were investigated in healthy male subjects after a single oral dose of 100mg/50μCi [14C] cetagliptin. The mean concentration-time profile of cetagliptin was similar to that of total radioactivity… read more here.
Keywords: cetagliptin healthy; 14c cetagliptin; cetagliptin; radioactivity ... See more keywords
1400. Mass Balance, Metabolism, and Excretion of [14C]-Plazomicin in Healthy Human Subjects
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1231
Abstract: Abstract Background Plazomicin is a next-generation aminoglycoside (AG) with a structure that protects it from common AG resistance mechanisms in Enterobacteriaceae, and with in vitro activity against extended spectrum β-lactamase-producing and carbapenem-resistant Enterobacteriaceae. The purpose… read more here.
Keywords: healthy human; plazomicin healthy; mass; 14c plazomicin ... See more keywords
Absorption, metabolism and excretion of opicapone in human healthy volunteers
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15383
Abstract: The absorption, metabolism and excretion of opicapone (2,5‐dichloro‐3‐(5‐[3,4‐dihydroxy‐5‐nitrophenyl]‐1,2,4‐oxadiazol‐3‐yl)‐4,6‐dimethylpyridine 1‐oxide), a selective catechol‐O‐methyltransferase inhibitor, were investigated. read more here.
Keywords: opicapone human; metabolism excretion; absorption metabolism; excretion opicapone ... See more keywords
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001006
Abstract: Human absorption, distribution, metabolism, and excretion (hADME) studies represent one of the most important clinical studies in terms of obtaining a comprehensive and quantitative overview of the total disposition of a drug. This article will… read more here.
Keywords: metabolism excretion; metabolism; distribution metabolism; absorption distribution ... See more keywords
A machine learning-based approach to ERα bioactivity and drug ADMET prediction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1087273
Abstract: By predicting ERα bioactivity and mining the potential relationship between Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) attributes in drug research and development, the development efficiency of specific drugs for breast cancer will be effectively improved… read more here.
Keywords: metabolism excretion; distribution metabolism; absorption distribution; prediction ... See more keywords
Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1026182
Abstract: Body-protective compound (BPC) 157 demonstrates protective effects against damage to various organs and tissues. For future clinical applications, we had previously established a solid-phase synthesis process for BPC157, verified its biological activity in different wound… read more here.
Keywords: body protective; metabolism excretion; bpc157; protective compound ... See more keywords
Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10030342
Abstract: Lycopene is a non-provitamin A carotenoid that exhibits several health benefits. Epidemiological data support a correlation between lycopene intake and the attenuation of several chronic diseases, including certain types of cancers and cardiovascular diseases. It… read more here.
Keywords: absorption; digestion absorption; absorption metabolism; metabolism excretion ... See more keywords
Artificial Intelligence in Drug Metabolism and Excretion Prediction: Recent Advances, Challenges, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041260
Abstract: Drug metabolism and excretion play crucial roles in determining the efficacy and safety of drug candidates, and predicting these processes is an essential part of drug discovery and development. In recent years, artificial intelligence (AI)… read more here.
Keywords: metabolism excretion; drug; prediction; drug metabolism ... See more keywords