A pilot study: Gut microbiota, metabolism and inflammation in hypertensive intracerebral haemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15622
Abstract: In recent years, the incidence rate of hypertensive intracerebral haemorrhage (HICH) has been increasing, accompanied by high mortality and morbidity, which has brought a heavy burden to the social economy. However, the pathogenesis of HICH… read more here.
Keywords: gut microbiota; intracerebral haemorrhage; metabolism inflammation; hypertensive intracerebral ... See more keywords
SP0105 Macrophages, metabolism and inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.7283
Abstract: Macrophages are a heterogeneity population implicated in several diseases and correlated with distinct tissue outcomes after injury. M2 macrophages have been associated with tissue repair whereas M1 macrophages participate in early phase of tissue damage.… read more here.
Keywords: sp0105 macrophages; macrophages metabolism; tissue; activation ... See more keywords
Abstract 6339: Reprogramming SREBP1-dependent metabolism and inflammation in high-risk breast with licochalcone A for the prevention of breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6339
Abstract: Breast cancer (BC) risk-reducing drugs have minimal impact due to their adverse effects and low acceptance. Novel non-endocrine agents with reduced toxicity and efficacy beyond HR+ BC are needed. We recently showed that in high-risk… read more here.
Keywords: metabolism inflammation; cancer; srebp1 dependent; dependent metabolism ... See more keywords
CHEK1 variant is a risk factor for premature ovarian insufficiency by mis- regulating metabolism and inflammation-related genes
Sign Up to like & getrecommendations! Published in 2025 at "Human Genomics"
DOI: 10.1186/s40246-025-00774-1
Abstract: Premature ovarian insufficiency (POI) is affecting approximately 1% of females and increasingly contributing to female infertility. The etiology of POI is heterogeneous. CHEK1, a critical component of the DNA damage and replication stress response, has… read more here.
Keywords: premature ovarian; chek1 variant; ovarian insufficiency; metabolism inflammation ... See more keywords
What Is the Role of Microglial Metabolism in Inflammation and Neurodegeneration?
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200920
Abstract: Microglia constitute the brain innate immune system and are epigenetically and transcriptionally distinct from other tissue-resident and bone marrow–derived macrophages.1,2 Under physiologic conditions, microglia actively survey their environment and maintain a unique gene expression signature… read more here.
Keywords: inflammation neurodegeneration; microglial metabolism; metabolism inflammation; receptors receptors ... See more keywords
CB2R Activation Regulates TFEB-Mediated Autophagy and Affects Lipid Metabolism and Inflammation of Astrocytes in POCD
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.836494
Abstract: Evidence suggests that the accumulation of lipid drots (LDs) accelerates damage to mitochondria and increases the release of inflammatory factors. These have been implicated as a mechanism underlying neurodegenerative diseases or tumors and aging-related diseases… read more here.
Keywords: cb2r activation; metabolism inflammation; lipid metabolism; activation ... See more keywords
Nutritional interventions for osteoarthritis: targeting the metabolism-inflammation-oxidative stress axis—clinical evidence and translational practice
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2025.1661136
Abstract: Osteoarthritis (OA) is the most common chronic joint disease worldwide. Increasing studies have confirmed that obesity, metabolic status and gut microbiota imbalance can promote the occurrence of OA through the “metabolism-inflammation-oxidative stress” network, which is… read more here.
Keywords: metabolism inflammation; inflammation oxidative; oxidative stress;
The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113339
Abstract: Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the PPAR group in the nuclear receptor superfamily, is a ligand-activated transcription factor. PPAR-δ regulates important cellular metabolic functions that contribute to maintaining energy balance. PPAR-δ… read more here.
Keywords: ppar; inflammation cancer; transcription factor; cancer ... See more keywords
Lipid Metabolism in Inflammation and Immune Function
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14071414
Abstract: Lipid metabolism plays an essential role in modulating inflammation within the context of acute and chronic diseases [...]. read more here.
Keywords: immune function; metabolism; lipid metabolism; metabolism inflammation ... See more keywords
Altered Metabolism and Inflammation Driven by Post-translational Modifications in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2024 at "Research"
DOI: 10.34133/research.0350
Abstract: Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain and a leading contributor to disability. IVDD progression involves pathological shifts marked by low-grade inflammation, extracellular matrix remodeling, and metabolic disruptions characterized by… read more here.
Keywords: metabolism inflammation; disc degeneration; intervertebral disc; inflammation ... See more keywords
Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022030
Abstract: Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase (Ch25h)… read more here.
Keywords: cholesterol; ch25h; metabolism inflammation; steatosis ... See more keywords