Metabolism of a new synthetic opioid tetrahydrofuranylfentanyl in fresh isolated human hepatocytes: detection and confirmation of ring-opened metabolites.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2743
Abstract: The metabolism of a new synthetic opioid tetrahydrofuranylfentanyl (THF-fentanyl) was investigated using fresh human hepatocytes. Fourteen metabolites of THF-fentanyl, such as tetrahydrofuran ring-opened metabolites, desphenethylated metabolites, hydroxylated metabolites, and hydroxylated and methoxylated metabolites and their… read more here.
Keywords: thf fentanyl; metabolism new; ring; ring opened ... See more keywords
Metabolism of a New Dipeptide Neuroprotector in Rats.
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DOI: 10.1007/s10517-022-05440-3
Abstract: Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis… read more here.
Keywords: new dipeptide; neuroprotector rats; dipeptide neuroprotector; neuroprotector ... See more keywords
Bioactive lipids and their metabolism: New therapeutic opportunities for Parkinson's disease
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DOI: 10.1111/ejn.15566
Abstract: Parkinson's disease (PD) is a neurological disorder characterized by motor dysfunction, which can also be associated with non‐motor symptoms. Its pathogenesis is thought to stem from a loss of dopaminergic neurons in the substantia nigra… read more here.
Keywords: lipids metabolism; parkinson disease; new therapeutic; bioactive lipids ... See more keywords
Retinoid metabolism: new insights.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0082
Abstract: Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell differentiation, and cell metabolism in many different cell types, both during embryogenesis and in the adult organism. However, we… read more here.
Keywords: metabolism vitamin; metabolism; metabolism new; retinoid metabolism ... See more keywords
Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1114459
Abstract: Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological variants. However, the disease penetrance… read more here.
Keywords: new therapeutic; metabolism; metabolism new; lipid metabolism ... See more keywords
Carotenoid metabolism: New insights and synthetic approaches
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1072061
Abstract: Carotenoids are well-known isoprenoid pigments naturally produced by plants, algae, photosynthetic bacteria as well as by several heterotrophic microorganisms. In plants, they are synthesized in plastids where they play essential roles in light-harvesting and in… read more here.
Keywords: metabolism; metabolism new; synthetic approaches; insights synthetic ... See more keywords
Metabolism as a New Avenue for Hepatocellular Carcinoma Therapy
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DOI: 10.3390/ijms24043710
Abstract: Hepatocellular carcinoma is today the sixth leading cause of cancer-related death worldwide, despite the decreased incidence of chronic hepatitis infections. This is due to the increased diffusion of metabolic diseases such as the metabolic syndrome,… read more here.
Keywords: hepatocellular carcinoma; metabolism new; new avenue; carcinoma therapy ... See more keywords
Sphingolipid Metabolism as a New Predictive Target Correlated with Aging and AD: A Transcriptomic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58040493
Abstract: Background and objectives: Alzheimer’s disease (AD) is the most common form of dementia characterized by memory loss and executive dysfunction. To date, no markers can effectively predict the onset of AD and an early diagnosis… read more here.
Keywords: metabolism; sphingolipid metabolism; metabolism new; new predictive ... See more keywords