Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.11.005
Abstract: In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in… read more here.
Keywords: glutamine metabolism; anti tumor; targeting glutamine; metabolism novel ... See more keywords
Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01533
Abstract: Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the macromolecules needed for their proper replication, they have evolved numerous strategies… read more here.
Keywords: hijacking supplies; metabolism novel; metabolism; host ... See more keywords