Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.07.013
Abstract: Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality with the potential to open target space not accessible to conventional small molecules via a degradation-based mechanism; however, their bifunctional nature can result in physicochemical properties that… read more here.
Keywords: metabolism pharmacokinetics; targeting chimeras; drug; proteolysis targeting ... See more keywords
Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12835
Abstract: Sanguinarine (SA) is a benzo[c] phenanthridine alkaloid which has a variety of pharmacological properties. However, very little was known about the pharmacokinetics of SA and its metabolite dihydrosanguinarine (DHSA) in pigs. The purpose of this… read more here.
Keywords: metabolism pharmacokinetics; vitro vivo; metabolism; sanguinarine metabolism ... See more keywords
Effects of Intestinal Microecology on Metabolism and Pharmacokinetics of Oral Wogonoside and Baicalin
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DOI: 10.1177/1934578x1701200412
Abstract: Baicalin and wogonoside are two of the most abundant flavonoid glycosides in the root of Scutellaria baicalensis Georgi, which is a widely used peroral herbal medicine with anticancer, antiviral, antibacterial and anti-inflammatory properties. In the… read more here.
Keywords: metabolism pharmacokinetics; baicalin; microecology metabolism; effects intestinal ... See more keywords
New Methods and Technology in Drugs Metabolism and Pharmacokinetics.
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DOI: 10.2174/138920022112201207111132
Abstract: read more here.
Keywords: metabolism pharmacokinetics; new methods; metabolism; technology drugs ... See more keywords
Metabolism and Pharmacokinetics of Phytochemicals in the Human Body.
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DOI: 10.2174/1389200221666200103090757
Abstract: BACKGROUND Phytochemicals are obtained from various plants and used for the treatment of diseases as both traditional and modern medicines. Poor bioavailability of phytochemicals is a major concern in applying phytochemicals as a therapeutic agent.… read more here.
Keywords: metabolism pharmacokinetics; human body; pharmacokinetics phytochemicals; metabolism ... See more keywords
Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version
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DOI: 10.3389/fphar.2022.937075
Abstract: Currently, many people are afflicted by cerebral diseases that cause dysfunction in the brain and perturb normal daily life of people. Cerebral diseases are greatly affected by cerebral metabolism, including the anabolism and catabolism of… read more here.
Keywords: metabolism pharmacokinetics; better bioactivity; cerebral metabolism; bioactivity cerebral ... See more keywords
Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo
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DOI: 10.3390/molecules27217469
Abstract: Lichens are among the most widely distributed plants on earth and have the longest growth cycle. Usnic acid is an abundant characteristic secondary metabolite of lichens and the earliest lichen compound used commercially. It has… read more here.
Keywords: bioactivity toxicity; usnic acid; pharmacokinetics usnic; metabolism pharmacokinetics ... See more keywords