Metabolism shapes the tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2017.05.006
Abstract: Tumors are strongly influenced by the surrounding normal tissue, which forms a specialized niche termed the tumor microenvironment (TME). The TME is modeled by cancer cells for their own benefit through a complex array of… read more here.
Keywords: tumor; metabolism shapes; tumor microenvironment; shapes tumor ... See more keywords
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
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DOI: 10.1016/j.cmet.2020.01.006
Abstract: Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics,… read more here.
Keywords: metabolism shapes; methionine; methionine metabolism; epigenetic reprogramming ... See more keywords
Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.02.003
Abstract: Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the priming and differentiation of CD4+ T cells into several distinct subsets including effector T helper (Th) 1, Th17 and Th2 cells,… read more here.
Keywords: metabolism shapes; metabolism; polarization; dendritic cells ... See more keywords