Abstract IA26: Exploiting altered metabolism as a therapeutic strategy for RAS-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia26
Abstract: We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppressed the growth of pancreatic ductal adenocarcinoma (PDAC) cell lines… read more here.
Keywords: inhibition; exploiting altered; therapeutic strategy; metabolism therapeutic ... See more keywords
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α.
Sign Up to like & getrecommendations! Published in 2017 at "Future cardiology"
DOI: 10.2217/fca-2016-0059
Abstract: This article provides a comprehensive review about the molecular and metabolic actions of PPAR-α. It describes its structural features, ligand specificity, gene transcription mechanisms, functional characteristics and target genes. In addition, recent progress with the… read more here.
Keywords: ppar; ppars regulators; metabolism therapeutic; therapeutic targets ... See more keywords
Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12121214
Abstract: Metabolism is a series of life-sustaining chemical reactions in organisms, providing energy required for cellular processes and building blocks for cellular constituents of proteins, lipids, carbohydrates and nucleic acids. Cancer cells frequently reprogram their metabolic… read more here.
Keywords: metabolism; cellular metabolism; thyroid cancer; metabolism therapeutic ... See more keywords