In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods.
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DOI: 10.1016/j.xphs.2017.04.045
Abstract: Evaluation of drug-drug interaction (DDI) risk is vital to establish benefit-risk profiles of investigational new drugs during drug development. In vitro experiments are routinely conducted as an important first step to assess metabolism- and transporter-mediated DDI… read more here.
Keywords: transporter mediated; vitro vivo; drug; vivo extrapolation ... See more keywords