Combined in silico and 19F NMR analysis of 5-fluorouracil metabolism in yeast at low ATP conditions
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DOI: 10.1042/bsr20192847
Abstract: Abstract The cytotoxic effect of 5-fluorouracil (5-FU) on yeast cells is thought to be mainly via a misincorporation of fluoropyrimidines into both RNA and DNA, not only DNA damage via inhibition of thymidylate synthase (TYMS)… read more here.
Keywords: fluorouracil; metabolism yeast; atp; combined silico ... See more keywords