Identification of Diagnostic Biomarkers for Colorectal Polyps Based on Noninvasive Urinary Metabolite Screening and Construction of a Nomogram
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70762
Abstract: Colorectal polyps (CRPs) are precursors to colorectal cancer (CRC), and early detection is crucial for prevention. Traditional diagnostic methods are invasive, prompting a need for noninvasive biomarkers. This study aimed to identify urinary metabolite biomarkers… read more here.
Keywords: metabolite; noninvasive urinary; colorectal polyps; metabolite screening ... See more keywords
Extraordinary long detection window of a synthetic cannabinoid metabolite in human urine - potential impact on therapeutic decisions.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2770
Abstract: Synthetic cannabinoids (SCs) have become established drugs of abuse. They play an increasing role in drug therapy, where abstinence control testing is required. Differentiation between recent drug uptake and uptake in the distant past is… read more here.
Keywords: drug; metabolite; detection window; urine samples ... See more keywords
A Novel High Resolution Mass Spectrometry-Based Analytical Strategy for Simultaneous Metabolite Profiling and Standard-Free Metabolite Quantification of Artemisinin in Human Liver Microsomes and Plasma.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of separation science"
DOI: 10.1002/jssc.70273
Abstract: Metabolite quantification without a radiolabeled analogue or the reference standard is challenging. This study presented a novel high resolution mass spectrometry (HRMS)-based analytical strategy for simultaneous metabolite profiling and standard-free metabolite quantification of drug candidates… read more here.
Keywords: based analytical; metabolite quantification; analytical strategy; metabolite ... See more keywords
Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23121
Abstract: Di‐(2‐ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine‐disrupting chemical (EDC) that has been shown to disrupt the function of… read more here.
Keywords: exposure; toxicity; mice; female reproductive ... See more keywords
Fecal corticosterone metabolite levels in two closely related rodent species in a sub‐Mediterranean environment
Sign Up to like & getrecommendations! Published in 2025 at "Wildlife Biology"
DOI: 10.1002/wlb3.01487
Abstract: Glucocorticoids regulate many physiological functions and play an important role in coping with challenging stimuli. The non‐invasive assessment of glucocorticoids is increasingly used as a tool to evaluate individual and population health status in wild… read more here.
Keywords: closely related; metabolite; two closely; fcm ... See more keywords
LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8579-1_15
Abstract: A method was developed for the analysis of stimulant drugs, opiates, synthetic opiates, PCP, and benzodiazepines in wastewater samples using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). A total of 33 compounds (stimulant-type drugs… read more here.
Keywords: metabolite; primary urinary; opiates pcp; opiates synthetic ... See more keywords
Pharmaceutical metabolite identification in lettuce (Lactuca sativa) and earthworms (Eisenia fetida) using liquid chromatography coupled to high-resolution mass spectrometry and in silico spectral library
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05515-2
Abstract: Pharmaceuticals released into the aquatic and soil environments can be absorbed by plants and soil organisms, potentially leading to the formation of unknown metabolites that may negatively affect these organisms or contaminate the food chain.… read more here.
Keywords: mass spectrometry; eisenia fetida; metabolite; mass ... See more keywords
Environmental monitoring and assessment of antibacterial metabolite producing actinobacteria screened from marine sediments in south coastal regions of Karnataka, India
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Monitoring and Assessment"
DOI: 10.1007/s10661-017-5999-y
Abstract: Assessment of the therapeutic potential of secondary metabolite producing microorganisms from the marine coastal areas imparts scope and application in the field of environmental monitoring. The present study aims to screen metabolites with antibacterial potential… read more here.
Keywords: environmental monitoring; south coastal; coastal regions; monitoring ... See more keywords
Nutrient-depended metabolic switching during batch cultivation of Streptomyces coelicolor explored with absolute quantitative mass spectrometry-based metabolite profiling
Sign Up to like & getrecommendations! Published in 2022 at "3 Biotech"
DOI: 10.1007/s13205-022-03146-x
Abstract: The well-known secondary metabolite-producing bacterium Streptomyces coelicolor is a natural choice for the development of super-hosts optimized for the heterologous expression of antibiotic biosynthetic gene clusters (BGCs). In this study, we used S. coelicolor M145… read more here.
Keywords: cultivation; limitation; mass; coelicolor ... See more keywords
Toward an evaluation of metabolite channeling in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.09.013
Abstract: Intermediates of metabolic pathways are sometimes contained within cavities of enzyme molecules and passed directly from active centers of one to next enzymes without diffusing into bulk matrix. This 'metabolite channeling' is postulated to have… read more here.
Keywords: toward evaluation; metabolite; evaluation metabolite; metabolite channeling ... See more keywords
Comprehensive hippocampal metabolite responses to PM2.5 in young mice.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.08.080
Abstract: Fine particulate matter (PM2.5) exposure alters brain development, clinical cognition and behavior in childhood. Previous studies of this subject have mainly been epidemiological investigations or analyses of gene and protein levels; however, gas chromatography-mass spectrometry… read more here.
Keywords: pm2; metabolism; metabolite; pm2 exposure ... See more keywords