A triple cysteine motif as major determinant of the modulation of neuronal KV7 channels by the paracetamol metabolite N‐acetyl‐p‐benzo quinone imine
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DOI: 10.1111/bph.16380
Abstract: The analgesic action of paracetamol involves KV7 channels, and its metabolite N‐acetyl‐p‐benzo quinone imine (NAPQI), a cysteine modifying reagent, was shown to increase currents through such channels in nociceptors. Modification of cysteine residues by N‐ethylmaleimide,… read more here.
Keywords: quinone imine; acetyl benzo; kv7 channels; metabolite acetyl ... See more keywords