CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.08.009
Abstract: With the advent of genome sequencing and mining technologies, secondary metabolite biosynthetic gene clusters (BGCs) within bacterial genomes are becoming easier to predict. For subsequent BGC characterization, clustered regularly interspaced short palindromic repeats (CRISPR) has… read more here.
Keywords: crage; secondary metabolite; crage crispr; biosynthetic gene ... See more keywords
Characterization of the secondary metabolite biosynthetic gene clusters in archaea
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.11.019
Abstract: Secondary metabolites are a range of bioactive compounds yielded by bacteria, fungi and plants, etc. The published archaea genomic data provide the opportunity for efficient identification of secondary metabolite biosynthetic gene clusters (BGCs) by genome… read more here.
Keywords: biosynthetic gene; gene clusters; secondary metabolite; metabolite biosynthetic ... See more keywords
sBGC-hm: an atlas of secondary metabolite biosynthetic gene clusters from the human gut microbiome
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad131
Abstract: Abstract Summary Microbial secondary metabolites exhibit potential medicinal value. A large number of secondary metabolite biosynthetic gene clusters (BGCs) in the human gut microbiome, which exhibit essential biological activity in microbe–microbe and microbe–host interactions, have… read more here.
Keywords: secondary metabolite; metabolite biosynthetic; biosynthetic gene; gene ... See more keywords
Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
Sign Up to like & getrecommendations! Published in 2018 at "Antibiotics"
DOI: 10.3390/antibiotics7040086
Abstract: Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity and… read more here.
Keywords: biosynthetic gene; diversity; specialized metabolite; gene clusters ... See more keywords
Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md21010029
Abstract: Recent reviews have reinforced sponge-associated bacteria as a valuable source of structurally diverse secondary metabolites with potent biological properties, which makes these microbial communities promising sources of new drug candidates. However, the overall diversity of… read more here.
Keywords: secondary metabolite; metabolite biosynthetic; biosynthetic gene; gene ... See more keywords