Cardiovascular Concentration-Effect Relationships of Amodiaquine and its Metabolite Desethylamodiaquine: Clinical and Pre-clinical Studies
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DOI: 10.1111/bcp.15569
Abstract: Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but… read more here.
Keywords: amodiaquine metabolite; effect relationships; metabolite desethylamodiaquine; relationships amodiaquine ... See more keywords
Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria
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DOI: 10.1186/s12936-020-03553-6
Abstract: Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target population groups. Methods… read more here.
Keywords: metabolite desethylamodiaquine; active metabolite; amodiaquine active; amodiaquine ... See more keywords