CYP2C9 Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid
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DOI: 10.3390/metabo12111106
Abstract: Polymorphisms in CYP2C9 can significantly interfere with the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen. The present research aimed to study the PK/PD parameters of naproxen and its metabolite,… read more here.
Keywords: metabolite desmethylnaproxen; oral fluid; cyp2c9; naproxen ... See more keywords