The Immunomodulatory Potential of the Metabolite Itaconate.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.05.007
Abstract: The field of immunometabolism has demonstrated that metabolites can lead double lives as immunomodulators. Itaconate is perhaps the best example of such a moonlighting molecule, and has been shown to have multiple anti-inflammatory effects in… read more here.
Keywords: metabolite itaconate; immunomodulatory potential; potential metabolite;
Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.885879
Abstract: Progressive bone loss during aging makes osteoporosis one of the most common and life impacting conditions in geriatric populations. The bone homeostasis is maintained through persistent remodeling mediated by bone-forming osteoblast and bone-resorbing osteoclast. Inflammaging,… read more here.
Keywords: itaconate; bone; bone loss; inflammatory bone ... See more keywords