Untangling the UV-B radiation-induced transcriptional network regulating plant morphogenesis and secondary metabolite production
Sign Up to like & getrecommendations! Published in 2021 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2021.104655
Abstract: Abstract Earlier, Ultraviolet-B (UV-B) radiations were considered to be detrimental to plant cells and their components. But recent researches have shown that it has multifaceted impacts on plants. The discovery of UV-B RESISTANCE 8 (UVR8)… read more here.
Keywords: plant morphogenesis; metabolite production; secondary metabolite; plant ... See more keywords
Optimizing bacterial resource allocation: metabolite production in continuous bioreactors
Sign Up to like & getrecommendations! Published in 2020 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2020.12.1146
Abstract: We show preliminary results addressing the problem of resource allocation in bacteria in the continuous bioreactor framework. We propose a coarse-grained self-replicator dynamical model that accounts for the microbial population growth inside a continuous bioreactor,… read more here.
Keywords: allocation; optimizing bacterial; resource allocation; production ... See more keywords
Expanding, integrating, sensing and responding: the role of primary metabolism in specialised metabolite production.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2019.03.006
Abstract: Producing specialised metabolites such as antibiotics, immunosuppressives, anti-cancer agents and anti-helminthics draws on primary metabolism to provide the building blocks for biosynthesis. The growth phase-dependent nature of production means that producing organisms must deal with… read more here.
Keywords: specialised metabolite; metabolism; metabolite production; primary metabolism ... See more keywords
Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00718
Abstract: Filamentous soil bacteria are known to produce diverse specialized metabolites. Despite having enormous potential as a source of pharmaceuticals, they often produce bioactive metabolites at low titers. Here, we show that inactivation of the pactamycin,… read more here.
Keywords: production; conglobatin; modulation specialized; metabolite production ... See more keywords
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13419-4
Abstract: Increased glucose uptake and metabolism is a prominent phenotype of most cancers, but efforts to clinically target this metabolic alteration have been challenging. Here, we present evidence that lactoylglutathione (LGSH), a byproduct of methylglyoxal detoxification,… read more here.
Keywords: metabolism; metabolite production; reactive metabolite; lung cancer ... See more keywords
Genetic Engineering of Microalgae for Secondary Metabolite Production: Recent Developments, Challenges, and Future Prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.836056
Abstract: Microalgae are highly diverse photosynthetic organisms with higher growth rate and simple nutritional requirements. They are evolved with an efficiency to adapt to a wide range of environmental conditions, resulting in a variety of genetic… read more here.
Keywords: genetic engineering; metabolite production; production; secondary metabolite ... See more keywords
Comparative Transcriptome Analysis Reveals Coordinated Transcriptional Regulation of Central and Secondary Metabolism in the Trichomes of Cannabis Cultivars
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158310
Abstract: Cannabis is one of the few plant genera capable of producing cannabinoids, the effects of which are synergized by terpene interactions. As the biosynthesis of both metabolite classes requires the same intracellular feedstocks, this work… read more here.
Keywords: cannabis cultivars; metabolite production; secondary metabolite; analysis ... See more keywords
Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087450
Abstract: The reprogramming of metabolism is a recognized cancer hallmark. It is well known that different signaling pathways regulate and orchestrate this reprogramming that contributes to cancer initiation and development. However, recent evidence is accumulating, suggesting… read more here.
Keywords: metabolite production; crosstalk metabolite; production signaling; signaling pathways ... See more keywords
Bioactive Metabolite Production in the Genus Pyrenophora (Pleosporaceae, Pleosporales)
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14090588
Abstract: The genus Pyrenophora includes two important cereal crop foliar pathogens and a large number of less well-known species, many of which are also grass pathogens. Only a few of these have been examined in terms… read more here.
Keywords: metabolite production; genus pyrenophora; bioactive metabolite;