Validation of LC–MS/MS methods for the determination of mirabegron and eight metabolites in human plasma in a paediatric population
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.007
Abstract: HighlightsThree analytical methods for mirabegron and metabolites in human plasma validated.Assays miniaturized for paediatric population by using 96‐well plate technology.Methodology utilized a more sensitive mass spectrometer than previously.Reduction in both assay volume and/or assay sensitivity… read more here.
Keywords: human plasma; mirabegron eight; metabolites human; mirabegron ... See more keywords
Direct infusion nano-electrospray ionization mass spectrometry for therapeutic drug monitoring of ciprofloxacin and its metabolites in human saliva.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113866
Abstract: A rapid and sensitive method based on direct infusion-nano-electrospray ionization mass spectrometry (DI-nESI-MS) has been developed for the detection and quantification of ciprofloxacin and its metabolites in human saliva. Saliva samples were collected after the… read more here.
Keywords: saliva; human saliva; ciprofloxacin; metabolites human ... See more keywords
Development and validation of a quantitative assay for the determination of cinacalcet and its main metabolites in human plasma using RP-HPLC method
Sign Up to like & getrecommendations! Published in 2017 at "Microchemical Journal"
DOI: 10.1016/j.microc.2016.10.017
Abstract: A novel and sensitive methodology for the quantitative determination of cinacalcet (CIN), and its main metabolites (M2a-Glu, M2b-Glu, M5, and M6) in plasma sample is suggested. The analytical assay is based on reversed-phase high-performance liquid… read more here.
Keywords: determination; human plasma; main metabolites; method ... See more keywords
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.04.022
Abstract: Summary PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown.… read more here.
Keywords: metabolism; metabolites human; bioactive metabolites; identification bioactive ... See more keywords
Development and Validation of a DLLME-GC-MS/MS Method for the Determination of Benzotriazole UV Stabilizer UV-327 and its Metabolites in Human Blood.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkac050
Abstract: 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used as an ultraviolet (UV) absorber in plastic materials and coatings. To investigate its metabolism and to assess human exposure, analytical methods are necessary for the determination of UV-327 and its metabolites… read more here.
Keywords: dllme; 327 metabolites; metabolites human; human blood ... See more keywords
Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical Biochemistry"
DOI: 10.1177/0004563219827045
Abstract: Background Tolvaptan is converted to major metabolites including three monohydroxylates (DM-4110, DM-4111 and DM-4119), an oxidate (MOP-21826) and a carboxylate (DM-4103) in humans. This study developed a simultaneous quantitative method for tolvaptan and its five… read more here.
Keywords: plasma; method; tolvaptan five; metabolites human ... See more keywords
Gut Mycobiota and Fungal Metabolites in Human Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug targets"
DOI: 10.2174/1389450119666180724125020
Abstract: BACKGROUND Accumulating evidence suggests that microbiota play an important role in host's homeostasis. Thus far, researchers have mostly focused on the role of bacterial microbiota. However, human gut is a habitat for several fungal species,… read more here.
Keywords: homeostasis; human homeostasis; fungal metabolites; metabolites human ... See more keywords