Direct and indirect quantification of phosphate metabolites of nucleoside analogs in biological samples.
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DOI: 10.1016/j.jpba.2019.112902
Abstract: Nucleoside reverse transcriptase inhibitors (NRTIs) are prodrugs that require intracellular phosphorylation to active triphosphate nucleotide metabolites (NMs) for their pharmacological activity. However, monitoring these pharmacologically active NMs is challenging due to their instability, high hydrophilicity,… read more here.
Keywords: phosphate metabolites; direct indirect; indirect quantification; quantification phosphate ... See more keywords