Determination of drugs of abuse and metabolites in plasma microsamples by LC-MS/MS after microQuEChERS extraction.
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DOI: 10.1080/17576180.2024.2404383
Abstract: Aim: Identifying drugs of abuse and their metabolites in plasma is vital in both forensic and clinical toxicology. While the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method offers an efficient approach to sample… read more here.
Keywords: microsamples microquechers; abuse metabolites; metabolites plasma; determination drugs ... See more keywords
Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma
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DOI: 10.1111/jphp.12798
Abstract: Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'‐DDE (dichlorodiphenylethene) and o,p'‐DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus,… read more here.
Keywords: adrenocortical carcinoma; mitotane; variation; metabolites plasma ... See more keywords