Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma
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DOI: 10.1111/jphp.12798
Abstract: Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'‐DDE (dichlorodiphenylethene) and o,p'‐DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus,… read more here.
Keywords: adrenocortical carcinoma; mitotane; variation; metabolites plasma ... See more keywords