CYP2C19 Metabolizer Status Does Not Influence the Safety or Efficacy of Pentamidine
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.596
Abstract: Background Pneumocystis jirovecii (PJP) infections are a significant cause of morbidity and mortality in recipients of hematopoietic cell transplantations (HCT), and PJP prophylaxis is a standard of care. The gold standard for PJP prophylaxis is… read more here.
Keywords: metabolizer status; cyp2c19 metabolizer; metabolizer; function ... See more keywords
Pharmacogenomics: Towards A New ERA Of Personalized Medicine In Psychiatry?
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.029
Abstract: Abstract Background Pharmacogenomics (PGx) is a field of study and clinical tool that assesses how genetic variability influences drug response and tolerability. CYP450 enzymes are responsible for metabolizing most psychiatric medications. Based on their genetic… read more here.
Keywords: medicine; response; treatment recommendations; study ... See more keywords
Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw388
Abstract: Objectives To characterize the effects of CYP2B6 polymorphisms, diurnal variation and demographic factors on nevirapine pharmacokinetics in African children. Methods Non-linear mixed-effects modelling conducted in NONMEM 7.3 described nevirapine plasma concentration–time data from 414 children… read more here.
Keywords: cyp2b6; effect; metabolizer; diurnal variation ... See more keywords
CYP2C19 loss of function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British-South Asian cohort.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15762
Abstract: BACKGROUND CYP2C19 is a hepatic enzyme involved in the metabolism of antidepressants associated with increased gastrointestinal bleed (GIB) risk. The aim of our study is to explore a possible association between loss of function CYP2C19… read more here.
Keywords: metabolizer; loss function; prevalence; cyp2c19 ... See more keywords
CYP2C19 metabolizer phenotypes may affect the efficacy of statins on lowering small dense low-density lipoprotein cholesterol of patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1016126
Abstract: Background Dyslipidemia is a major cause of arteriosclerotic cardiovascular disease (ASCVD), and low-density lipoprotein cholesterol (LDL-C) is the profile to be reduced to prevent disease progression. Small dense low-density lipoprotein cholesterol (sdLDL-C) has been proven… read more here.
Keywords: cyp2c19 metabolizer; efficacy statins; metabolizer; metabolizer phenotypes ... See more keywords
Impact of UGT1A1 Polymorphisms on Febrile Neutropenia in Pancreatic Cancer Patients Receiving FOLFIRINOX: A Single-Center Cohort Study
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DOI: 10.3390/cancers14051244
Abstract: Simple Summary FOLFIRINOX, which is a first-line chemotherapy for metastatic pancreatic cancer, has become one of the high-risk regimens related to developing febrile neutropenia (FN). Although UGT1A1 polymorphisms are associated with the metabolism of irinotecan,… read more here.
Keywords: metabolizer; pancreatic cancer; ugt1a1 polymorphisms; group ... See more keywords