Drug Metabolizing Enzyme and Transporter Genes Associated with Plasma Risperidone Level in Thai Autism Spectrum Disorder
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DOI: 10.1016/j.eurpsy.2017.02.196
Abstract: Background The associations between genetic variants of drug metabolizing enzyme and transporter (DMET) genes and steady-state plasma concentrations of risperidone, 9-hydroxyrisperidone, total active-moiety, and metabolic ratio remain unclear. Objective The objective of the present study… read more here.
Keywords: drug metabolizing; enzyme transporter; associated plasma; risperidone ... See more keywords
Polymorphisms of drug-metabolizing enzyme CYP2E1 in Chinese Uygur population
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DOI: 10.1097/md.0000000000009970
Abstract: Abstract Pharmacogenetics is the genetic basis of pharmacokinetics, genetic testing, and clinical management in diseases. Evaluation about genetic alterations of drug metabolizing enzymes in human genome contributes toward understanding the interindividual and interethnic variability for… read more here.
Keywords: drug metabolizing; cyp2e1; uygur population; metabolizing enzyme ... See more keywords
High-altitude Hypoxia Influences the Activities of the Drug-Metabolizing Enzyme CYP3A1 and the Pharmacokinetics of Four Cardiovascular System Drugs
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DOI: 10.3390/ph15101303
Abstract: (1) Background: High-altitude hypoxia has been shown to affect the pharmacokinetic properties of drugs. Although there is a high incidence of cardiovascular disease among individuals living in high-altitude areas, studies on the effect of high-altitude… read more here.
Keywords: altitude hypoxia; metabolizing enzyme; drug metabolizing; high altitude ... See more keywords