Glycan‐metabolizing enzymes in microbe–host interactions: the Streptococcus pneumoniae paradigm
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13045
Abstract: Streptococcus pneumoniae is a frequent colonizer of the upper airways; however, it is also an accomplished pathogen capable of causing life‐threatening diseases. To colonize and cause invasive disease, this bacterium relies on a complex array… read more here.
Keywords: streptococcus pneumoniae; metabolizing enzymes; host; glycan metabolizing ... See more keywords
Quantitative Proteomics of Hepatic Drug‐Metabolizing Enzymes and Transporters in Patients With Colorectal Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2633
Abstract: The impact of liver cancer metastasis on protein abundance of 22 drug‐metabolizing enzymes (DMEs) and 25 transporters was investigated using liquid chromatography‐tandem accurate mass spectrometry targeted proteomics. Microsomes were prepared from liver tissue taken from… read more here.
Keywords: cancer metastasis; drug metabolizing; metabolizing enzymes; drug ... See more keywords
Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2232-x
Abstract: Studies on the metabolic fate of medical drugs, skin care products, cosmetics and other chemicals intentionally or accidently applied to the human skin have become increasingly important in order to ascertain pharmacological effectiveness and to… read more here.
Keywords: pig; xenobiotica metabolizing; skin models; skin ... See more keywords
Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4030-3
Abstract: CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D. In this review, we summarize the clinical aspects of CYP3A-mediated metabolism of tacrolimus and vitamin D with emphasis on… read more here.
Keywords: drug metabolizing; tacrolimus vitamin; enzymes cyp3a; metabolizing enzymes ... See more keywords
Nitrile Metabolizing Enzymes in Biocatalysis and Biotransformation
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-018-2705-7
Abstract: Nitrile metabolizing enzymes, i.e., aldoxime dehydratase, hydroxynitrile lyase, nitrilase, nitrile hydratase, and amidase, are the key catalysts in carbon nitrogen triple bond anabolism and catabolism. Over the past several years, these enzymes have drawn considerable… read more here.
Keywords: biochemistry; biocatalysis biotransformation; enzymes biocatalysis; metabolizing enzymes ... See more keywords
A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.012
Abstract: The flavon luteolin has various health-promoting activities including cardiovascular protection, anti-inflammatory activity and anticancer activity. A serum concentration of about 100 nM luteolin is reached by dietary habit. However, little is known about the function of… read more here.
Keywords: drug metabolizing; phase drug; physiological concentration; metabolizing enzymes ... See more keywords
Ultrastructural characterization of vitamin D receptors and metabolizing enzymes in the lipid droplets of the fatty liver in rat.
Sign Up to like & getrecommendations! Published in 2020 at "Acta Histochemica"
DOI: 10.1016/j.acthis.2020.151502
Abstract: Abstract Vitamin D is a steroid hormone with numerous actions in the organism. There are strong evidences that relate vitamin D deficiency with liver lipid metabolism disturbances, but the mechanism of this action is still… read more here.
Keywords: rat; microscopy; high sucrose; lipid droplets ... See more keywords
Age-associated expression of vitamin D receptor and vitamin D-metabolizing enzymes in the male reproductive tract and sperm of Hu sheep.
Sign Up to like & getrecommendations! Published in 2018 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2018.01.003
Abstract: The cellular response to 1,25-dihydroxyvitamin D3 (Vit D3; biologically active form of Vitamin D) is complex and depends not only on Vitamin D receptor (VDR) expression but also on cellular uptake of circulating Vit D3… read more here.
Keywords: reproductive tract; metabolizing enzymes; expression; vitamin metabolizing ... See more keywords
Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.01.001
Abstract: Antibiotics act on bacterial flora originally present in the intestine, and changes in the intestinal flora have various effects on the host. This study investigated changes in the protein levels of drug transporters and metabolizing… read more here.
Keywords: antibiotic treated; transporters metabolizing; drug; metabolizing enzymes ... See more keywords
mRNA levels of drug-metabolizing enzymes in 11 brain regions of cynomolgus macaques.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.12.003
Abstract: The cynomolgus macaque is an important nonhuman primate species in drug metabolism studies, in part because of its evolutionary closeness to humans. Cytochromes P450 (P450s) have been investigated in the major drug-metabolizing organs, i.e., the… read more here.
Keywords: drug metabolizing; enzymes brain; drug; brain regions ... See more keywords
Genetic Diseases of Vitamin D Metabolizing Enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2017.07.011
Abstract: Vitamin D metabolism involves 3 highly specific cytochrome P450 (CYP) enzymes (25-hydroxylase, 1α-hydroxylase, and 24-hydroxylase) involved in the activation of vitamin D3 to the hormonal form, 1,25-(OH)2D3, and the inactivation of 1,25-(OH)2D3 to biliary excretory… read more here.
Keywords: endocrinology; metabolizing enzymes; vitamin metabolizing; diseases vitamin ... See more keywords