A systematic evaluation of quenching and extraction procedures for quantitative metabolome profiling of HeLa carcinoma cell under 2D and 3D cell culture conditions
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology Journal"
DOI: 10.1002/biot.202200444
Abstract: Metabolic reprogramming has been coined as a hallmark of cancer, accompanied by which the alterations in metabolite levels have profound effects on gene expression, cellular differentiation, and the tumor environment. Yet a systematic evaluation of… read more here.
Keywords: cell; quantitative metabolome; quenching extraction; hela carcinoma ... See more keywords
Perturbations of gut microbiome and metabolome of pigs infected with Mycoplasma hyorhinis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12690
Abstract: BACKGROUND Mycoplasma hyorhinis is a prevalent respiratory pathogen in swine, causing significant economic loss to pig producers. There is growing evidence that respiratory pathogen infections have a great impact on intestinal microecology. To study the… read more here.
Keywords: metabolism; pigs infected; mycoplasma hyorhinis; metabolome ... See more keywords
Fast Sampling of the Cellular Metabolome.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1585-0_2
Abstract: Obtaining meaningful snapshots of the metabolome of microorganisms requires rapid sampling and immediate quenching of all metabolic activity, to prevent any changes in metabolite levels after sampling. Furthermore, a suitable extraction method is required ensuring… read more here.
Keywords: extraction; cellular metabolome; metabolome; sampling cellular ... See more keywords
Variation of the microbiota and metabolome along the canine gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2017 at "Metabolomics"
DOI: 10.1007/s11306-017-1165-3
Abstract: IntroductionThe fecal microbiota are relevant to the health and disease of many species. The importance of the fecal metabolome has more recently been appreciated, but our knowledge of the microbiota and metabolome at other sites… read more here.
Keywords: gastrointestinal tract; microbiota metabolome; metabolome; along canine ... See more keywords
Differential transcriptome and metabolome analysis of Plumbago zeylanica L. reveal putative genes involved in plumbagin biosynthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104761
Abstract: Plumbagin is a pharmacologically active naphthoquinone present in the Plumbago zeylanica L. having important medicinal properties. The root of P. zeylanica is rich and primary tissue of the plumbagin biosynthesis and accumulation. The complete biosynthetic… read more here.
Keywords: metabolome; zeylanica; plumbagin; plumbagin biosynthesis ... See more keywords
Intestinal microbiota, metabolome and gender dimorphism in autism spectrum disorders
Sign Up to like & getrecommendations! Published in 2018 at "Research in Autism Spectrum Disorders"
DOI: 10.1016/j.rasd.2018.01.009
Abstract: Abstract There is a male predominance in autism, with a male/female ratio of 4:1 and an even higher ratio (11:1) in individuals with high functioning autism. The reasons for gender differences in ASD are unknown.… read more here.
Keywords: gender dimorphism; autism; metabolome; intestinal microbiota ... See more keywords
Bacterial colonization reprograms the neonatal gut metabolome
Sign Up to like & getrecommendations! Published in 2020 at "Nature microbiology"
DOI: 10.1038/s41564-020-0694-0
Abstract: Initial microbial colonization and later succession in the gut of human infants are linked to health and disease later in life. The timing of the appearance of the first gut microbiome, and the consequences for… read more here.
Keywords: metabolome; amino acids; colonization; neonatal gut ... See more keywords
Integrated metagenome and metabolome analyses of blood pressure studies in early postmenopausal Chinese women
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002832
Abstract: Supplemental Digital Content is available in the text Objective: We carried out sensitivity analyses on gut microbiota metagenomic sequencing, untargeted metabolome, targeted metabolome for short-chain fatty acids (SCFAs) and human whole genome sequencing from 402… read more here.
Keywords: metabolome; early postmenopausal; variation; postmenopausal chinese ... See more keywords
PECTIN ACETYLESTERASE9 Affects the Transcriptome and Metabolome and Delays Aphid Feeding1 [OPEN].
Sign Up to like & getrecommendations! Published in 2019 at "Plant physiology"
DOI: 10.1104/pp.19.00635
Abstract: The plant cell wall plays an important role in damage-associated molecular pattern-induced resistance to pathogens and herbivorous insects. Our current understanding of cell wall-mediated resistance is largely based on the degree of pectin methylesterification. However,… read more here.
Keywords: pae9; metabolome; acetylesterase9 affects; pectin ... See more keywords
Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13821
Abstract: Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of "omic" techniques that are closer to phenotype, such as metabolomics, to the study of the aging process… read more here.
Keywords: sex; metabolome; aromatic amino; process ... See more keywords
Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00710-22
Abstract: As the world becomes increasingly industrialized, understanding the biological consequences of these lifestyle shifts and what it means for past, present, and future human health is critical. Indeed, industrialization is associated with rises in allergic… read more here.
Keywords: human fecal; fecal metabolome; metabolome; shared human ... See more keywords