Articles with "metabolome" as a keyword



A systematic evaluation of quenching and extraction procedures for quantitative metabolome profiling of HeLa carcinoma cell under 2D and 3D cell culture conditions

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Published in 2023 at "Biotechnology Journal"

DOI: 10.1002/biot.202200444

Abstract: Metabolic reprogramming has been coined as a hallmark of cancer, accompanied by which the alterations in metabolite levels have profound effects on gene expression, cellular differentiation, and the tumor environment. Yet a systematic evaluation of… read more here.

Keywords: cell; quantitative metabolome; quenching extraction; hela carcinoma ... See more keywords

Perturbations of gut microbiome and metabolome of pigs infected with Mycoplasma hyorhinis.

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Published in 2023 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.12690

Abstract: BACKGROUND Mycoplasma hyorhinis is a prevalent respiratory pathogen in swine, causing significant economic loss to pig producers. There is growing evidence that respiratory pathogen infections have a great impact on intestinal microecology. To study the… read more here.

Keywords: metabolism; pigs infected; mycoplasma hyorhinis; metabolome ... See more keywords
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Fast Sampling of the Cellular Metabolome.

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Published in 2022 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1585-0_2

Abstract: Obtaining meaningful snapshots of the metabolome of microorganisms requires rapid sampling and immediate quenching of all metabolic activity, to prevent any changes in metabolite levels after sampling. Furthermore, a suitable extraction method is required ensuring… read more here.

Keywords: extraction; cellular metabolome; metabolome; sampling cellular ... See more keywords

Variation of the microbiota and metabolome along the canine gastrointestinal tract

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Published in 2017 at "Metabolomics"

DOI: 10.1007/s11306-017-1165-3

Abstract: IntroductionThe fecal microbiota are relevant to the health and disease of many species. The importance of the fecal metabolome has more recently been appreciated, but our knowledge of the microbiota and metabolome at other sites… read more here.

Keywords: gastrointestinal tract; microbiota metabolome; metabolome; along canine ... See more keywords

A specific diagnostic metabolome signature in adult IgA vasculitis

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Published in 2024 at "Metabolomics"

DOI: 10.1007/s11306-024-02107-0

Abstract: IgA vasculitis diagnosis relies primarily on clinical features and is confirmed by pathological findings. To date, there is no reliable noninvasive diagnostic biomarker. We aimed to explore the baseline serum metabolome of adult patients with… read more here.

Keywords: vasculitis; adult iga; iga vasculitis; patients iga ... See more keywords

Differential transcriptome and metabolome analysis of Plumbago zeylanica L. reveal putative genes involved in plumbagin biosynthesis.

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Published in 2020 at "Fitoterapia"

DOI: 10.1016/j.fitote.2020.104761

Abstract: Plumbagin is a pharmacologically active naphthoquinone present in the Plumbago zeylanica L. having important medicinal properties. The root of P. zeylanica is rich and primary tissue of the plumbagin biosynthesis and accumulation. The complete biosynthetic… read more here.

Keywords: metabolome; zeylanica; plumbagin; plumbagin biosynthesis ... See more keywords

Intestinal microbiota, metabolome and gender dimorphism in autism spectrum disorders

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Published in 2018 at "Research in Autism Spectrum Disorders"

DOI: 10.1016/j.rasd.2018.01.009

Abstract: Abstract There is a male predominance in autism, with a male/female ratio of 4:1 and an even higher ratio (11:1) in individuals with high functioning autism. The reasons for gender differences in ASD are unknown.… read more here.

Keywords: gender dimorphism; autism; metabolome; intestinal microbiota ... See more keywords
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Bacterial colonization reprograms the neonatal gut metabolome

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Published in 2020 at "Nature microbiology"

DOI: 10.1038/s41564-020-0694-0

Abstract: Initial microbial colonization and later succession in the gut of human infants are linked to health and disease later in life. The timing of the appearance of the first gut microbiome, and the consequences for… read more here.

Keywords: metabolome; amino acids; colonization; neonatal gut ... See more keywords

Deconvolution of Human Urine across the Transcriptome and Metabolome

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Published in 2024 at "Clinical chemistry"

DOI: 10.1093/clinchem/hvae137

Abstract: BACKGROUND: Early detection of the cell type changes underlying several genitourinary tract diseases largely remains an unmet clinical need, where existing assays, if available, lack the cellular resolution afforded by an invasive biopsy. While messenger… read more here.

Keywords: cfrna; human urine; cell; metabolome ... See more keywords

Oral amoxicillin treatment disrupts the gut microbiome and metabolome without interfering with luminal redox potential in the intestine of Wistar Han rats

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Published in 2025 at "FEMS Microbiology Ecology"

DOI: 10.1093/femsec/fiaf003

Abstract: Abstract Oral antibiotic treatment is well known to be one of the main factors affecting gut microbiota composition by altering bacterial diversity. It decreases the abundance of butyrate-producing bacteria such as Lachnospiraceae and Ruminococcaceae, while… read more here.

Keywords: treatment; redox potential; amoxicillin treatment; oral amoxicillin ... See more keywords

The recipient metabolome explains the asymmetric ovarian impact on fetal sex development after embryo transfer in cattle

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Published in 2024 at "Journal of Animal Science"

DOI: 10.1093/jas/skae081

Abstract: Abstract In cattle, lateral asymmetry affects ovarian function and embryonic sex, but the underlying molecular mechanisms remain unknown. The plasma metabolome of recipients serves to predict pregnancy after embryo transfer (ET). Thus, the aim of… read more here.

Keywords: embryo transfer; day day; sex; metabolome ... See more keywords