Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.12.025
Abstract: Metabolomics has become an invaluable tool for both studying metabolism and biomarker discovery. The great technical advances in analytical chemistry and bioinformatics have considerably increased the number of measurable metabolites, yet an important part of… read more here.
Keywords: sample preparation; reviewing metabolome; preparation; metabolome coverage ... See more keywords
Enhancing metabolome coverage in data-dependent LC-MS/MS analysis through an integrated feature extraction strategy.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02980
Abstract: In untargeted metabolomics, conventional data preprocessing software (e.g., XCMS, MZmine 2, MS-DIAL) are used extensively due to their high efficiency in metabolic feature extraction. However, these programs present limitations in recognizing low-abundance metabolic features, thus… read more here.
Keywords: extraction; metabolic features; metabolome coverage; integrated feature ... See more keywords