Metabolomics analysis of the hippocampus in a rat model of traumatic brain injury during the acute phase
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1520
Abstract: Traumatic brain injury (TBI) has increased in rank among traumatic injuries worldwide. Traumatic brain injury is a serious obstacle given that its complex pathology represents a long‐term process. Recently, systems biology strategies such as metabolomics… read more here.
Keywords: traumatic brain; analysis hippocampus; brain injury; brain ... See more keywords
Biomarkers for pancreatic cancer based on tissue and serum metabolomics analysis in a multicenter study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5296
Abstract: Early detection of pancreatic ductal adenocarcinoma (PDAC) may improve the prognosis of patients. This study was to identify metabolic features of PDAC and to discover early detection biomarkers for PDAC by tissue and serum metabolomics… read more here.
Keywords: serum metabolomics; tissue serum; metabolomics analysis;
Urinary metabolomics analysis of the protective effects of Daming capsule on hyperlipidemia rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100113
Abstract: Hyperlipidemia is recognized as one of the most important risk factors for morbidity and mortality due to cardiovascular diseases. Daming capsule, a Chinese patent medicine, has shown definitive efficacy in patients with hyperlipidemia. In this… read more here.
Keywords: hyperlipidemia; urinary metabolomics; capsule; daming capsule ... See more keywords
Investigation on the immunotoxicity induced by Emamectin benzoate on THP‐1 macrophages based on metabolomics analysis
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23747
Abstract: Emamectin benzoate (EMB) is an insecticide extensively used in agricultural area. Assessing the toxic effects of EMB in mammals or humans and its endogenous metabolites alteration are the appropriate means of evaluating its risks to… read more here.
Keywords: macrophages based; immunotoxicity; based metabolomics; analysis ... See more keywords
Metabolomics Analysis of Glutamate Receptor Function.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9077-1_11
Abstract: Metabolomics analysis provides a unique opportunity for comprehensive mapping of glutamatergic system function using high-throughput metabolite analysis and providing a perspective of the enzymatic activity, which cannot be obtained by other systems biology techniques. read more here.
Keywords: analysis; glutamate receptor; biology; analysis glutamate ... See more keywords
13C-assisted metabolomics analysis reveals the positive correlation between specific erythromycin production rate and intracellular propionyl-CoA pool size in Saccharopolyspora erythraea
Sign Up to like & getrecommendations! Published in 2017 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-017-1792-0
Abstract: Metabolomics analysis is extremely essential to explore the metabolism characteristics of Saccharopolyspora erythraea. The lack of suitable methods for the determination of intracellular metabolites, however, hinders the application of metabolomics analysis for S. erythraea. Acyl-CoAs… read more here.
Keywords: pool; metabolomics analysis; propionyl coa; erythromycin production ... See more keywords
Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats
Sign Up to like & getrecommendations! Published in 2020 at "BioMetals"
DOI: 10.1007/s10534-020-00260-2
Abstract: This study aims to explore the protective effects of quercetin against cadmium-induced nephrotoxicity utilizing metabolomics methods. Male Sprague–Dawley rats were randomly assigned to six groups: control, different dosages of quercetin (10 and 50 mg/kg·bw, respectively), CdCl2… read more here.
Keywords: effects quercetin; analysis effects; cadmium; acid ... See more keywords
Urinary metabolomics analysis reveals the anti-diabetic effect of stachyose in high-fat diet/streptozotocin-induced type 2 diabetic rats.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115534
Abstract: As a new platform of systems biology, metabolomics provides a powerful approach to discover therapeutic biomarkers and mechanism of metabolic disease. Type 2 diabetes mellitus (T2DM) is a global metabolic disease, thus, a urinary metabolomics… read more here.
Keywords: fat diet; urinary metabolomics; high fat; anti diabetic ... See more keywords
Recent advances in metabolomics analysis for early drug development.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.02.018
Abstract: The pharmaceutical industry adapted proteomics and other 'omics technologies for drug research early following their initial introduction. Although metabolomics lacked behind in this development, it has now become an accepted and widely applied approach in… read more here.
Keywords: development; early drug; drug; metabolomics analysis ... See more keywords
Identification of low-molecular-weight color contributors of black tea infusion by metabolomics analysis based on UV-visible spectroscopy and mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Food chemistry"
DOI: 10.1016/j.foodchem.2022.132788
Abstract: Nine black tea samples with different color intensity were firstly determined by chromatic difference analyzer. The color characteristics were secondly quantitatively described by UV-visible spectroscopy. Thirdly, liquid chromatography tandem mass spectrometry (LC-MS) based metabolomics analysis… read more here.
Keywords: mass; spectroscopy; metabolomics analysis; color ... See more keywords
Metabolomics Analysis of Nutrient Metabolism in β-Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.07.020
Abstract: The islets of Langerhans harbor multiple endocrine cell-types that continuously respond to circulating nutrient levels in order to adjust their secretion of catabolic and anabolic hormones. Stimulus-secretion coupling in these cells is largely of metabolic… read more here.
Keywords: secretion; metabolism cells; metabolism; nutrient metabolism ... See more keywords