Isotope‐Guided Metabolomics Reveals Divergent Incorporation of Valine into Different Flavor Precursor Classes in Chives
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300056
Abstract: Plants of the genus Allium such as chives, onions or garlic produce S‐alk(en)yl cysteine sulfoxides as flavor precursors. Two major representatives are S‐propenyl cysteine sulfoxide (isoalliin) and S‐propyl cysteine sulfoxide (propiin), which only differ by… read more here.
Keywords: guided metabolomics; metabolomics reveals; valine; reveals divergent ... See more keywords
Precise Metabolomics Reveals a Diversity of Aging‐Associated Metabolic Features
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200130
Abstract: Mass spectrometry‐based metabolomics has emerged as a powerful technique for biomedical research, although technical issues with its analytical precision and structural characterization remain. Herein, a robust non‐targeted strategy for accurate quantitation and precise profiling of… read more here.
Keywords: metabolism; metabolic features; metabolomics reveals; precise metabolomics ... See more keywords
Metabolomics reveals the reproductive abnormality in female zebrafish exposed to environmentally relevant levels of climbazole.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.116665
Abstract: Climbazole (CBZ) ubiquitously detected in the aquatic environment may disrupt fish reproductive function. Thus far, the previous study has focused on its transcriptional impact of steroidogenesis-related genes on zebrafish, but the underlying toxic mechanism still… read more here.
Keywords: reproductive abnormality; metabolomics reveals; zebrafish exposed; abnormality female ... See more keywords
GW29-e1007 Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.845
Abstract: The development and maintenance of pulmonary arterial hypertension (PAH) involves in multiple metabolic abnormalities, but the specific mechanism remains elusive. We aimed to further explore the underlying mechanism and look for new biomarkers for diagnosis… read more here.
Keywords: arterial hypertension; e1007 metabolomics; metabolomics reveals; pulmonary arterial ... See more keywords
Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23110-1
Abstract: Pretomanid is a promising anti-tubercular drug currently at clinical phase III, but its mechanisms of action are currently unclear. This study aimed to: (i) reveal the metabolome of Mycobacterium smegmatis under pretomanid treatment; (ii) compare… read more here.
Keywords: pretomanid; metabolomics reveals; pretomanid treatment; reveals new ... See more keywords
Metabolomics reveals that PPARα activation protects against lithocholic acid-induced liver injury
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra08823j
Abstract: Some studies have reported that the activation of peroxisome proliferator-activated receptor alpha (PPARα) could protect against liver injury-induced by chemicals. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOFMS)-based… read more here.
Keywords: induced liver; metabolomics reveals; ppar activation; liver injury ... See more keywords
Metabolomics reveals sex‐specific pathways associated with changes in adiposity and muscle mass in a cohort of Mexican adolescents
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Obesity"
DOI: 10.1111/ijpo.12887
Abstract: Alterations in body composition (BC) during adolescence relates to future metabolic risk, yet underlying mechanisms remain unclear. read more here.
Keywords: pathways associated; metabolomics reveals; specific pathways; reveals sex ... See more keywords
Metabolomics reveals new metabolic perturbations in children with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Diabetes"
DOI: 10.1111/pedi.12524
Abstract: Using an untargeted metabolomics approach we investigated the metabolome of children with type 1 diabetes (T1D) in comparison with healthy peers and explored the contribution of HbA1c and clinical features to the observed difference. read more here.
Keywords: metabolomics reveals; type diabetes; new metabolic; reveals new ... See more keywords
Urinary metabolomics reveals the biological characteristics of early pregnancy in pigs
Sign Up to like & getrecommendations! Published in 2022 at "Porcine Health Management"
DOI: 10.1186/s40813-022-00256-z
Abstract: Background Embryo implantation in sows is an important event during pregnancy. During this process, blastocysts undergo dramatic morphologic changes, and the endometrium becomes receptive. Studies have shown that developmental changes associated with the crosstalk between… read more here.
Keywords: early pregnancy; metabolomics reveals; urinary metabolomics; pregnancy ... See more keywords
Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4126738
Abstract: Microplastic exposure leads to various toxic effects in Daphnia magna; however, the effects of microplastics on the metabolic processes in D. magna and the corresponding molecular toxicity mechanisms remain unclear. In the present study, the… read more here.
Keywords: mps mps; metabolomics reveals; toxicity; reveals mechanism ... See more keywords
Untargeted serum metabolomics reveals potential biomarkers and metabolic pathways associated with esophageal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.938234
Abstract: Metabolomics has been reported as an efficient tool to screen biomarkers that are related to esophageal cancer. However, the metabolic biomarkers identifying malignant degrees and therapeutic efficacy are still largely unknown in the disease. Here,… read more here.
Keywords: esophageal cancer; metabolomics reveals; untargeted serum; serum metabolomics ... See more keywords