Control of neuronal excitability by Group I metabotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0301-7
Abstract: Metabotropic glutamate (mGlu) receptors couple through G proteins to regulate a large number of cell functions. Eight mGlu receptor isoforms have been cloned and classified into three Groups based on sequence, signal transduction mechanisms and… read more here.
Keywords: glutamate receptors; metabotropic glutamate; group metabotropic; metabotropic ... See more keywords
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
Sign Up to like & getrecommendations! Published in 2017 at "ACS Central Science"
DOI: 10.1021/acscentsci.6b00353
Abstract: Phenylazopyridines are photoisomerizable compounds with high potential to control biological functions with light. We have obtained a series of phenylazopyridines with light dependent activity as negative allosteric modulators (NAM) of metabotropic glutamate receptor subtype 5… read more here.
Keywords: metabotropic glutamate; photoswitch metabotropic; phenylazopyridines photoswitch; illuminating phenylazopyridines ... See more keywords
Abstract PR13: Pivotal role of interleukin 23 in osteosarcoma development and its link with glutamate metabotropic 4: Identification of novel therapeutic targets for osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Omics A Journal of Integrative Biology"
DOI: 10.1158/1557-3265.sarcomas17-pr13
Abstract: Objective: The 5-year survival of patients with metastatic or recurrent osteosarcoma is less than 25%. There is an urgent need to identify new treatment options for this cancer. Osteosarcomas represent a promising indication for strategies… read more here.
Keywords: il23; osteosarcoma; cancer; glutamate ... See more keywords
Structural insights into the activation of metabotropic glutamate receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.2210/pdb6n50/pdb
Abstract: Metabotropic glutamate receptors are family C G-protein-coupled receptors. They form obligate dimers and possess extracellular ligand-binding Venus flytrap domains, which are linked by cysteine-rich domains to their 7-transmembrane domains. Spectroscopic studies show that signalling is… read more here.
Keywords: metabotropic glutamate; glutamate receptors; cysteine rich; activation ... See more keywords
Adenosine Metabotropic Receptors in Chronic Pain Management
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.651038
Abstract: The pharmacological treatment of chronic pain is still unsatisfactory. The cellular and molecular mechanisms at the basis of pain chronification are still poorly understood. The commercially available drugs for treating chronic pain, including neuropathic pain,… read more here.
Keywords: neuropathic pain; adenosine; metabotropic; chronic pain ... See more keywords
Microtransplantation of Postmortem Native Synaptic mGluRs Receptors into Xenopus Oocytes for Their Functional Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12100931
Abstract: Metabotropic glutamate receptors (mGluRs) are membrane receptors that play a central role in the modulation of synaptic transmission and neuronal excitability and whose dysregulation is implicated in diverse neurological disorders. Most current understanding about the… read more here.
Keywords: glutamate; microtransplantation postmortem; metabotropic; group ... See more keywords