Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26362
Abstract: Ophelia syndrome or encephalitis with antibodies against the metabotropic glutamate receptor 5 (mGluR5) manifests with behavioral changes, memory deficits, and anxiety. To study the antibody pathogenicity, mice received continuous cerebroventricular infusion of patients' or controls'… read more here.
Keywords: receptor antibodies; human metabotropic; glutamate receptor; metabotropic glutamate ... See more keywords
Allosteric Molecular Switches in Metabotropic Glutamate Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000444
Abstract: Metabotropic glutamate receptors (mGlu) are class C G protein‐coupled receptors of eight subtypes that are omnipresently expressed in the central nervous system. mGlus have relevance in several psychiatric and neurological disorders, therefore they raise considerable interest… read more here.
Keywords: allosteric molecular; metabotropic glutamate; switches metabotropic; molecular switches ... See more keywords
CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24003
Abstract: It is well recognized that astrocytes can produce factors known to affect the myelination process. One such factor, brain‐derived neurotrophic factor (BDNF), can enhance the differentiation of oligodendrocyte lineage cells following a demyelinating lesion. Our… read more here.
Keywords: myelin proteins; metabotropic glutamate; myelination; chpg ... See more keywords
ONIOM and FMO-EDA study of metabotropic glutamate receptor 1: Quantum insights into the allosteric binding site
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Quantum Chemistry"
DOI: 10.1002/qua.25617
Abstract: The crystal structure of metabotropic glutamate receptor 1 (mGluR1) complexed with 4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide (FITM, a negative allosteric modulator) and its twelve close structural analogs with a broad spectrum of affinities (2.4 nM 10 000 nM) were investigated… read more here.
Keywords: oniom fmo; fmo eda; metabotropic glutamate; glutamate receptor ... See more keywords
Mechanisms and functional impact of Group I metabotropic glutamate receptor modulation of excitability in mouse MNTB neurons
Sign Up to like & getrecommendations! Published in 2019 at "Synapse"
DOI: 10.1002/syn.22137
Abstract: We examined effects of Group I metabotropic glutamate receptors on the excitability of mouse medial nucleus of the trapezoid body (MNTB) neurons. The selective agonist, S‐3,5‐dihydroxyphenylglycine (DHPG), evoked a dose‐dependent depolarization of the resting potential,… read more here.
Keywords: metabotropic glutamate; group; excitability mouse; mntb neurons ... See more keywords
Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5031-4
Abstract: RationalePost-traumatic stress disorder (PTSD) is a devastating anxiety-related disorder which develops subsequent to a severe psychologically traumatic event. Only ~ 9% of people who experience such a trauma develop PTSD. It is clear that a number… read more here.
Keywords: metabotropic glutamate; extinction; mglu7 receptor; receptor mrna ... See more keywords
Control of neuronal excitability by Group I metabotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0301-7
Abstract: Metabotropic glutamate (mGlu) receptors couple through G proteins to regulate a large number of cell functions. Eight mGlu receptor isoforms have been cloned and classified into three Groups based on sequence, signal transduction mechanisms and… read more here.
Keywords: glutamate receptors; metabotropic glutamate; group metabotropic; metabotropic ... See more keywords
Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicity Research"
DOI: 10.1007/s12640-021-00449-4
Abstract: The aim of this study is to investigate the changes in expression of metabotropic glutamate (Glu) receptor subtype 1 (mGluR1), a key molecule involved in neuroexcitetoxicity, during excessive Glu release in the brain by PET… read more here.
Keywords: glu; release; metabotropic glutamate; receptor subtype ... See more keywords
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109648
Abstract: Summary Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors activated by the main excitatory neurotransmitter, L-glutamate. mGluR activation by agonists binding in the venus flytrap domain is regulated by positive (PAM) or negative (NAM) allosteric… read more here.
Keywords: metabotropic glutamate; allosteric modulators; agonists allosteric; receptor ... See more keywords
Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.12.001
Abstract: HighlightsAlzheimer's disease is an incurable neurodegenerative disease causing such a severe dementia to interfere with daily life.Pathognomonic lesions of Alzheimer's disease are plaques of &bgr;‐amyloid, neurofibrillary tangles and neuronal loss.Alterations of the glutamatergic transmission contribute… read more here.
Keywords: alzheimer disease; metabotropic glutamate; glutamate receptors; disease ... See more keywords
Metabotropic glutamate receptors as targets for novel anxiolytics
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2018.02.004
Abstract: HighlightsPositive correlation between mGlu5 receptor signaling and anxiety‐related symptoms.mGlu5 receptor NAMs reduce OCD‐like symptoms in preclinical studies.Activation of mGlu4 receptors abolishes chronic pain‐induced anxiety in mice.Therapeutic potential of mGlu receptor modulation for anxiety disorders. &NA;… read more here.
Keywords: targets novel; metabotropic glutamate; anxiety disorders; mglu ... See more keywords