Regulation of hepcidin/iron-signalling pathway interactions by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.11.009
Abstract: Increased concentration of ferrous iron in the gastrointestinal tract increases the number of various pathogens and induces inflammation. LPS and/or high-fat diet-associated metaflammation is mediated through a quaternary receptor signaling complex containing iron-regulated pathway, IL-6/STAT… read more here.
Keywords: metaflammation; inhibition; lps oleate; hepcidin iron ... See more keywords
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
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DOI: 10.1038/s41574-018-0059-4
Abstract: Ageing and age-related diseases share some basic mechanistic pillars that largely converge on inflammation. During ageing, chronic, sterile, low-grade inflammation — called inflammaging — develops, which contributes to the pathogenesis of age-related diseases. From an… read more here.
Keywords: metaflammation; age related; age; metabolic diseases ... See more keywords
The Western lifestyle has lasting effects on metaflammation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-019-0156-1
Abstract: Chronic consumption of a Western diet along with sedentary behaviour causes chronic metabolic inflammation (termed metaflammation) and is ‘memorized’ by innate immune cells through long-lasting metabolic and epigenetic cellular reprogramming. Lifestyle-associated pathologies have reached epidemic… read more here.
Keywords: effects metaflammation; metaflammation; lifestyle lasting; western lifestyle ... See more keywords
Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.839436
Abstract: Metabolic syndrome refers to obesity-associated metabolic disorders that increase the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. Environmental imbalance during the early developmental period affects health and increases susceptibility to non-communicable… read more here.
Keywords: dohad theory; metabolic syndrome; developmental origins; metaflammation ... See more keywords
A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice
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DOI: 10.3389/fimmu.2021.701275
Abstract: Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM… read more here.
Keywords: hfd; metaflammation; peptide designed; synthetic peptide ... See more keywords