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   Articles with "metal binding" as a keyword



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Identification of Adenosine Deaminase Inhibitors by Metal‐binding Pharmacophore Screening

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recommendations! Published in 2020 at "ChemMedChem"

DOI: 10.1002/cmdc.202000271

Abstract: Adenosine deaminase (ADA) is a human mononuclear Zn2+ metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics… read more here.

Keywords: deaminase inhibitors; inhibitors metal; metal binding; identification adenosine ... See more keywords

Prediction of Protein Metal Binding Sites Using Deep Neural Networks

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recommendations! Published in 2019 at "Molecular Informatics"

DOI: 10.1002/minf.201800169

Abstract: Metals have crucial roles for many physiological, pathological and diagnostic processes. Metal binding proteins or metalloproteins are important for metabolism functions. The proteins that reach the three‐dimensional structure by folding show which vital function is… read more here.

Keywords: metal binding; prediction protein; metal; binding sites ... See more keywords

Distribution of phytochelatins, metal-binding compounds, in plant foods: A survey of commonly consumed fruits, vegetables, grains and legumes.

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recommendations! Published in 2020 at "Food chemistry"

DOI: 10.1016/j.foodchem.2020.128051

Abstract: Phytochelatins (PyCs) are metal-binding compounds produced by plants. PyCs may reduce bioavailability of dietary toxic metals such as cadmium. However, the PyC concentrations in foods are unknown. The objective of this study was to analyze… read more here.

Keywords: plant foods; commonly consumed; metal binding; binding compounds ... See more keywords

Oligopeptide models of the metal binding loop of the bacterial copper efflux regulator protein CueR as potential Cu(I) chelators

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recommendations! Published in 2017 at "Inorganica Chimica Acta"

DOI: 10.1016/j.ica.2017.06.062

Abstract: Abstract Copper(I) binding features of oligopeptides, mimicking the metal binding loops (MBL) of the bacterial copper efflux regulator protein CueR, were investigated with an aim of exploring potential candidates for Cu(I)-sequestration. Two of the studied… read more here.

Keywords: regulator protein; copper efflux; copper; metal binding ... See more keywords

1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation.

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recommendations! Published in 2017 at "International journal of mass spectrometry"

DOI: 10.1016/j.ijms.2016.09.018

Abstract: The early oligomerization of amyloid β-protein (Aβ) is a crucial step in the etiology of Alzheimer's disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside neurons. In search of therapeutic… read more here.

Keywords: terminal metal; penta galloyl; metal binding; galloyl glucopyranose ... See more keywords
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The metal-binding properties of the long chaplin from Streptomyces mobaraensis: A bioinformatic and biochemical approach.

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recommendations! Published in 2019 at "Journal of inorganic biochemistry"

DOI: 10.1016/j.jinorgbio.2019.110878

Abstract: Chaplins are amphiphilic proteins coating the surface of aerial hyphae under formation of amyloid-like rodlet layers in streptomycetes. The long chaplin from Streptomyces mobaraensis, Sm-Chp1, harbors extended histidine-rich stretches allowing protein attachment to metal affinity… read more here.

Keywords: metal binding; metal; mobaraensis; long chaplin ... See more keywords
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Metal Sensing by DNA.

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recommendations! Published in 2017 at "Chemical reviews"

DOI: 10.1021/acs.chemrev.7b00063

Abstract: Metal ions are essential to many chemical, biological, and environmental processes. In the past two decades, many DNA-based metal sensors have emerged. While the main biological role of DNA is to store genetic information, its… read more here.

Keywords: dna sequences; dna; metal binding; metal ... See more keywords

Unified Modeling Approach for Quantifying the Proton and Metal Binding Ability of Soil Dissolved Organic Matter.

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recommendations! Published in 2022 at "Environmental science & technology"

DOI: 10.1021/acs.est.2c08482

Abstract: Soil dissolved organic matter (DOM) is composed of a mass of complex organic compounds in soil solutions and significantly affects a range of (bio)geochemical processes in soil environment. However, how the chemical complexity (i.e., heterogeneity… read more here.

Keywords: ability; soil; soil dom; metal binding ... See more keywords

Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds.

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recommendations! Published in 2022 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.2c00891

Abstract: The use of metal-binding pharmacophores (MBPs) in fragment-based drug discovery has proven effective for targeted metalloenzyme drug development. However, MBPs can still suffer from pharmacokinetic liabilities. Bioisostere replacement is an effective strategy utilized by medicinal… read more here.

Keywords: chemistry; metalloenzyme inhibitor; binding isosteres; drug ... See more keywords

Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides

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recommendations! Published in 2022 at "Inorganic Chemistry"

DOI: 10.1021/acs.inorgchem.2c02584

Abstract: It is supposed that the presence of poly-His regions in close proximity to poly-Gly domains in snake venoms is related to their biological activity; poly-His/poly-Gly (pHpG) peptides inhibit the activity of metalloproteinases during venom storage… read more here.

Keywords: poly gly; accessibility; poly; metal binding ... See more keywords

Computational Study of Amyloidβ42 Familial Mutations and Metal Interaction: Impact on Monomers and Aggregates Dynamical Behaviors

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recommendations! Published in 2024 at "Inorganic Chemistry"

DOI: 10.1021/acs.inorgchem.3c04555

Abstract: One of the main hallmarks of Alzheimer’s Disease is the formation of β-amyloid plaques, whose formation may be enhanced by metal binding or the appearance of familial mutations. In the present study, the simultaneous effect… read more here.

Keywords: computational study; study amyloid; familial mutations; metal binding ... See more keywords