Identification of Adenosine Deaminase Inhibitors by Metal‐binding Pharmacophore Screening
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000271
Abstract: Adenosine deaminase (ADA) is a human mononuclear Zn2+ metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics… read more here.
Keywords: deaminase inhibitors; inhibitors metal; metal binding; identification adenosine ... See more keywords
Prediction of Protein Metal Binding Sites Using Deep Neural Networks
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Informatics"
DOI: 10.1002/minf.201800169
Abstract: Metals have crucial roles for many physiological, pathological and diagnostic processes. Metal binding proteins or metalloproteins are important for metabolism functions. The proteins that reach the three‐dimensional structure by folding show which vital function is… read more here.
Keywords: metal binding; prediction protein; metal; binding sites ... See more keywords
Distribution of phytochelatins, metal-binding compounds, in plant foods: A survey of commonly consumed fruits, vegetables, grains and legumes.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.128051
Abstract: Phytochelatins (PyCs) are metal-binding compounds produced by plants. PyCs may reduce bioavailability of dietary toxic metals such as cadmium. However, the PyC concentrations in foods are unknown. The objective of this study was to analyze… read more here.
Keywords: plant foods; commonly consumed; metal binding; binding compounds ... See more keywords
Oligopeptide models of the metal binding loop of the bacterial copper efflux regulator protein CueR as potential Cu(I) chelators
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.06.062
Abstract: Abstract Copper(I) binding features of oligopeptides, mimicking the metal binding loops (MBL) of the bacterial copper efflux regulator protein CueR, were investigated with an aim of exploring potential candidates for Cu(I)-sequestration. Two of the studied… read more here.
Keywords: regulator protein; copper efflux; copper; metal binding ... See more keywords
1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of mass spectrometry"
DOI: 10.1016/j.ijms.2016.09.018
Abstract: The early oligomerization of amyloid β-protein (Aβ) is a crucial step in the etiology of Alzheimer's disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside neurons. In search of therapeutic… read more here.
Keywords: terminal metal; penta galloyl; metal binding; galloyl glucopyranose ... See more keywords
The metal-binding properties of the long chaplin from Streptomyces mobaraensis: A bioinformatic and biochemical approach.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.110878
Abstract: Chaplins are amphiphilic proteins coating the surface of aerial hyphae under formation of amyloid-like rodlet layers in streptomycetes. The long chaplin from Streptomyces mobaraensis, Sm-Chp1, harbors extended histidine-rich stretches allowing protein attachment to metal affinity… read more here.
Keywords: metal binding; metal; mobaraensis; long chaplin ... See more keywords
Metal Sensing by DNA.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00063
Abstract: Metal ions are essential to many chemical, biological, and environmental processes. In the past two decades, many DNA-based metal sensors have emerged. While the main biological role of DNA is to store genetic information, its… read more here.
Keywords: dna sequences; dna; metal binding; metal ... See more keywords
Unified Modeling Approach for Quantifying the Proton and Metal Binding Ability of Soil Dissolved Organic Matter.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08482
Abstract: Soil dissolved organic matter (DOM) is composed of a mass of complex organic compounds in soil solutions and significantly affects a range of (bio)geochemical processes in soil environment. However, how the chemical complexity (i.e., heterogeneity… read more here.
Keywords: ability; soil; soil dom; metal binding ... See more keywords
Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c00891
Abstract: The use of metal-binding pharmacophores (MBPs) in fragment-based drug discovery has proven effective for targeted metalloenzyme drug development. However, MBPs can still suffer from pharmacokinetic liabilities. Bioisostere replacement is an effective strategy utilized by medicinal… read more here.
Keywords: chemistry; metalloenzyme inhibitor; binding isosteres; drug ... See more keywords
Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.2c02584
Abstract: It is supposed that the presence of poly-His regions in close proximity to poly-Gly domains in snake venoms is related to their biological activity; poly-His/poly-Gly (pHpG) peptides inhibit the activity of metalloproteinases during venom storage… read more here.
Keywords: poly gly; accessibility; poly; metal binding ... See more keywords
Experimental Determination of pKa Values and Metal Binding for Biomolecular Compounds Using 31P NMR Spectroscopy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Education"
DOI: 10.1021/acs.jchemed.7b00508
Abstract: This lab experiment uses 31P NMR spectroscopy of biomolecules to determine pKa values and the binding energies of metal/biomolecule complexes. Solutions of adenosine nucleotides are prepared, and a series of 31P NMR spectra are collected… read more here.
Keywords: 31p nmr; pka values; nmr spectroscopy; metal binding ... See more keywords