Diverse crystalline protein scaffolds through metal‐dependent polymorphism
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.4971
Abstract: As protein crystals are increasingly finding diverse applications as scaffolds, controlled crystal polymorphism presents a facile strategy to form crystalline assemblies with controllable porosity with minimal to no protein engineering. Polymorphs of consensus tetratricopeptide repeat… read more here.
Keywords: polymorphism; protein; metal; metal coordination ... See more keywords
Peroxide reduction by a metal-dependent catalase in Nostoc punctiforme (cyanobacteria)
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8130-y
Abstract: This study investigated the role of a novel metal-dependent catalase (Npun_R4582) that reduces hydrogen peroxide in the cyanobacterium Nostoc punctiforme. Quantitative real-time PCR showed that npun_R4582 relative mRNA levels were upregulated by over 16-fold in… read more here.
Keywords: dependent catalase; metal dependent; npun r4582; r4582 ... See more keywords
SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease
Sign Up to like & getrecommendations! Published in 2024 at "Biometals"
DOI: 10.1007/s10534-024-00596-z
Abstract: Over recent years, we have been living under a pandemic, caused by the rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). One of the major virulence factors of Coronaviruses is the Non-structural… read more here.
Keywords: dna rna; sars cov2; nsp1 metal; metal dependent ... See more keywords
Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.011
Abstract: Amyloids are protein aggregates of highly regular structure that are involved in diverse pathologies such as Alzheimer's and Parkinson's disease. Recent evidence has shown that under certain conditions, small peptides can self-assemble into amyloids that… read more here.
Keywords: novel catalytic; metal dependent; amyloid displaying; catalytic amyloid ... See more keywords
Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.05.044
Abstract: Quantum chemical calculations are today an extremely valuable tool for studying enzymatic reaction mechanisms. In this mini-review, we summarize our recent work on several metal-dependent decarboxylases, where we used the so-called cluster approach to decipher… read more here.
Keywords: non redox; decarboxylase; quantum chemical; mechanisms metal ... See more keywords
Metal-Dependent Umpolung Reactivity of Carbenes Derived from Cyclopropenes
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.04.001
Abstract: Summary Metal carbenes, divalent carbon species, are versatile intermediates that enable novel synthetic pathways. These species exhibit either electrophilic or nucleophilic character, depending on the carbene and metal fragments. Although the metal carbene reactivity is… read more here.
Keywords: carbene reactivity; metal; dependent umpolung; reactivity ... See more keywords
Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00216
Abstract: Alzheimer's disease (AD) is one of the most devastating forms of dementia, without reliable treatments to cure, delay the onset, or prevent the disease progression. The proposed toxic mechanisms of AD include amyloidogenesis of amyloid… read more here.
Keywords: multifaceted toxicity; alzheimer disease; dependent independent; toxicity ... See more keywords
Co-assembled Coiled-Coil Peptide Nanotubes with Enhanced Stability and Metal-Dependent Cargo Loading
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01669
Abstract: Peptide nanotube biomaterials are attractive for their range of applications. Herein, we disclose the co-assembly of coiled-coil peptides, one with ligands for metal ions that demonstrate hierarchical assembly into nanotubes, with spatial control of the… read more here.
Keywords: coil peptide; enhanced stability; coiled coil; metal dependent ... See more keywords
Metal-dependent photosensitivity of three isostructural 1D CPs based on the 1,1'-bis(3-carboxylatobenzyl)-4,4'-bipyridinium moiety.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt00157k
Abstract: To study the effect of metal ions on the photochromic behaviors of CPs, three new isostructural coordination polymers (CPs) based on a neutral viologen moiety, 1,1'-bis(3-carboxylatobenzyl)-4,4'-bipyridinium (bcbpy), have been obtained by choosing 1,2,4,5-benzenetetracarboxylic acid (H4BTEC)… read more here.
Keywords: carboxylatobenzyl bipyridinium; bis carboxylatobenzyl; metal; metal dependent ... See more keywords
Comparative analysis of the metal-dependent structural and functional properties of mouse and human SMP30
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0218629
Abstract: Senescence Marker Protein (SMP30) is a metalloenzyme that shows lactonase activity in the ascorbic acid (AA) biosynthesis pathway in non-primate mammals such as a mouse. However, AA biosynthesis does not occur in the primates including… read more here.
Keywords: presence; human smp30; mouse human; metal dependent ... See more keywords
Metal-dependent programmed cell death-related lncRNA prognostic signatures and natural drug sensitivity prediction for gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1039499
Abstract: Background: Gastric cancer is one of the most important malignancies with poor prognosis. Ferroptosis and cuproptosis are newly discovered metal-dependent types of programmed cell death, which may directly affect the outcome of gastric cancer. Long… read more here.
Keywords: cell death; gastric cancer; metal dependent; programmed cell ... See more keywords