Protein metalation in a nutshell
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14500
Abstract: Metalation, the acquisition of metals by proteins, must avoid mis‐metalation with tighter binding metals. This is illustrated by four selected proteins that require different metals: all show similar ranked orders of affinity for bioavailable metals,… read more here.
Keywords: metalation; series; metalation nutshell; protein metalation ... See more keywords
Ferrochelatase π-helix: Implications from examining the role of the conserved π-helix glutamates in porphyrin metalation and product release.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.02.015
Abstract: Protoporphyrin ferrochelatase catalyzes the insertion of Fe2+ into protoporphyrin IX to form heme. To determine whether a conserved, active site π-helix contributes to the translocation of the metal ion substrate to the ferrochelatase-bound porphyrin substrate,… read more here.
Keywords: metalation; ferrochelatase helix; helix glutamates; helix ... See more keywords
Protein metalation in biology.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.102095
Abstract: Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding… read more here.
Keywords: metalation; protein metalation; metalation biology; biology ... See more keywords
Structure model of ferrochelatase from Salmonella Typhi elucidating metalation mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.01.066
Abstract: A homology model of ferrochelatase (HemH), the heme biosynthesis terminal step enzyme from Salmonella Typhi was generated to understand the mechanism of metal insertion into protoporphyrin IX for heme biosynthesis. The overall fold of membrane… read more here.
Keywords: metalation; mechanism; ferrochelatase; model ferrochelatase ... See more keywords
Metalation and DFT studies of metal organic frameworks UiO-66(Zr) with vanadium chloride as allyl alcohol epoxidation catalyst
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.126940
Abstract: Abstract UiO-66(Zr)-V as metal organic framework was prepared by metalation of the UiO-66(Zr) nodes with VCl3. The characterization of the prepared catalyst was carried out using XRD, EDX, FT IR, BET, ICP, Raman, DRS, SEM… read more here.
Keywords: catalyst; metalation; dft studies; vanadium ... See more keywords
Efficient DNA-Catalyzed Porphyrin Metalation for Fluorescent Ratiometric Pb2+ Detection.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02759
Abstract: Developing biosensors for Pb2+ is an important analytical topic. DNA-based Pb2+ sensors have been designed mainly based on RNA-cleaving DNAzymes and Pb2+-induced folding of G-quadruplex (G4) DNA. Porphyrin metalation is a key reaction in biology… read more here.
Keywords: pb2; detection; metalation; dna ... See more keywords
Selective Metalation and Functionalization of Fluorinated Nitriles Using 2,2,6,6-Tetramethylpiperidyl Bases.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02572
Abstract: We have accomplished regioselective deprotometalation of aromatic and heteroaromatic nitriles via (TMP)2Zn·2MgCl2·2LiCl and TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) with the exploration of new and scarcely investigated metalation positions. Regioselectivity was rationalized by DFT calculations. The quenching… read more here.
Keywords: metalation; metalation functionalization; tetramethylpiperidyl; fluorinated nitriles ... See more keywords
Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01961
Abstract: For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on α-metalation, the second is based on direct C-H functionalization. A new library of sophisticated… read more here.
Keywords: approaches functionalization; metalation; parallel approaches; thietes metalation ... See more keywords
Kinetic versus thermodynamic metalation enables synthesis of isostructural homo- and heterometallic trinuclear clusters.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc02346a
Abstract: Temperature-dependent metalation of the new hexadentate ligand (tris(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane; H3TPM) enables the selective synthesis of both mononuclear (i.e. Na(THF)4[Fe(TPM)], kinetic product) and trinuclear (i.e. Fe3(TPM)2, thermodynamic product) complexes. Exposure of Na(THF)4[Fe(TPM)] to FeCl2 or ZnCl2 triggers… read more here.
Keywords: versus thermodynamic; metalation; homo heterometallic; heterometallic trinuclear ... See more keywords
Phosphorescent biaryl platinum(IV) complexes obtained through double metalation of dibenzoiodolium ions.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01018f
Abstract: The first series of neutral, tris-chelate, phosphorecent Pt(IV) complexes is reported, which combine two cyclometalated 2-arylpyridine ligands and a dimetalated biaryl. The introduction of biaryl ligands is achieved under mild conditions through the oxidative addition… read more here.
Keywords: metalation; platinum complexes; dibenzoiodolium; dibenzoiodolium ions ... See more keywords
Charge and adsorption height dependence of the self-metalation of porphyrins on ultrathin MgO(001) films
Sign Up to like & getrecommendations! Published in 2022 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d2cp04688a
Abstract: We have experimentally determined the adsorption structure, charge state, and metalation state of porphin, the fundamental building block of porphyrins, on ultrathin Ag(001)-supported MgO(001) films by scanning tunneling microscopy and photoemission spectroscopy, supported by calculations… read more here.
Keywords: adsorption; metalation; 001 films; self metalation ... See more keywords