Genetic and Biochemical Characterization of VMB‐1, a Novel Metallo‐β‐Lactamase Encoded by a Conjugative, Broad‐Host Range IncC Plasmid from Vibrio spp
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900221
Abstract: The increasing incidence of phenotypic resistance to carbapenems in recent years is mainly attributed to acquisition of mobile carbapenemase‐encoding genetic elements by major bacterial pathogens. Here, a novel carbapenemase known as Vibrio metallo‐β‐lactamase 1 (VMB‐1),… read more here.
Keywords: vmb; vibrio; metallo; incc ... See more keywords
1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100699
Abstract: Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-negative pathogens. Unfortunately, clinically efficient MBL inhibitors still represent an unmet medical need . We previously reported several series… read more here.
Keywords: triazole thione; metallo; vim; vim type ... See more keywords
Terpyridine-based Three-dimensional Discrete Metallo-supramolecular Architectures.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200004
Abstract: Terpyridine (tpy)-based three-dimensional (3D) discrete metallo-supramolecular architectures, which are often inspired by the biological structures found in nature, have drawn significant attention from the community of metallo-supramolecular chemistry. Because of the linear tpy-M(II)-tpy connectivity, however,… read more here.
Keywords: discrete metallo; metallo supramolecular; metallo; tpy ... See more keywords
Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114174
Abstract: Antibiotic resistance caused by β-lactamases, particularly metallo-β-lactamases, has been a major threat to public health globally. New Delhi metallo-β-lactamase-1 (NDM-1) represents one of the most important metallo-β-lactamases; the production of NDM-1 in bacterial pathogen significantly… read more here.
Keywords: new delhi; metallo lactamases; metallo; stereochemically altered ... See more keywords
Phytotoxicity and genotoxicity as a new approach to assess heavy metals effect on Medicago sativa L.: Role of metallo-resistant rhizobacteria
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Technology and Innovation"
DOI: 10.1016/j.eti.2021.101833
Abstract: Abstract The present work deals with the phytotoxicity and the genotoxicity of three heavy metals, namely copper, lead, and zinc on Medicago sativa seeds germination. Indeed, the role of metallo-resistant bacteria in lessening heavy metal… read more here.
Keywords: phytotoxicity genotoxicity; metallo resistant; heavy metals; metallo ... See more keywords
Facile construction of terpridine-based metallo-polymers in hydrogels, crystals and solutions directed by metal ions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.03.051
Abstract: Driven by tunable metal-ligand interactions, a polydentate ligand TC containing terpyridine and carboxylic acid units was developed to construct metallo-polymers that showed multiple aggregation modes with controlled macroscopic properties. In the presence of different kind… read more here.
Keywords: based metallo; metallo polymers; metal ligand; metallo ... See more keywords
Mutation and evolution of metallo-beta-lactamase CphA under the selective pressure of biapenem continuous concentration gradient.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2022.111776
Abstract: One of the resistance mechanisms of superbugs is to hydrolyze antibiotics by producing metallo-β-lactamases (MβLs). To verify how MβLs evolved to increase in activity in response to various β-lactam antibiotics, the mutation and evolution of… read more here.
Keywords: cpha; metallo; mutation evolution; binding pocket ... See more keywords
Large B7 Triangles in Hollow Spherical Trihedral Metallo-borospherenes and Their Endohedral Complexes of B20TMn (TM = Sc, Y; n = 3, 4): a Theoretical Characterization.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c00624
Abstract: The spherical trihedral metallo-borospherene D3h B18Ln3- (Ln = La, Tb), in which both Ln and B atoms are integral parts of the cage surface, represents a brand new geometric structure. On the basis of particle… read more here.
Keywords: metallo borospherene; spherical trihedral; metallo; trihedral metallo ... See more keywords
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01257
Abstract: Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. Here, we describe a series of 1,2,4-triazole-3-thione-based inhibitors… read more here.
Keywords: clinical isolates; potent synergistic; synergistic activity; metallo ... See more keywords
Understanding Charge-Transfer Characteristics in Crystalline Nanosheets of Fullerene/(Metallo)porphyrin Cocrystals.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b06162
Abstract: Cocrystals in the form of crystalline nanosheets comprised of C70 and (metallo)porphyrins were prepared by using the liquid-liquid interfacial precipitation (LLIP) method where full control over the morphologies in the C70/(metallo)porphyrins nanosheets has been accomplished… read more here.
Keywords: metallo porphyrin; metallo; charge transfer;
Highly Stable Spherical Metallo-Capsule from a Branched Hexapodal Terpyridine and Its Self-Assembled Berry-type Nanostructure.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10707
Abstract: Discrete spherical metallo-organic capsules at the nanometer scale, especially those constructed from unique building blocks, have received significant attention recently because of their fascinating molecular aesthetics and potential applications due to their compact cavities. Here,… read more here.
Keywords: terpyridine; spherical metallo; berry type; metallo nanosphere ... See more keywords